INT18990

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 5.22
Pain Relevance 11.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRP) extracellular space (GRP) extracellular region (GRP)
Anatomy Link Frequency
interneurons 3
colon 1
central nervous system 1
gut 1
neurons 1
GRP (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 23 100.00 Very High Very High Very High
Enkephalin 14 100.00 Very High Very High Very High
Somatostatin 14 99.80 Very High Very High Very High
Pyramidal cell 162 99.32 Very High Very High Very High
Chronic pancreatitis 21 98.84 Very High Very High Very High
Central nervous system 10 98.60 Very High Very High Very High
gABA 54 98.48 Very High Very High Very High
Anterior cingulate cortex 288 98.00 Very High Very High Very High
antagonist 67 97.88 Very High Very High Very High
qutenza 15 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 8 99.52 Very High Very High Very High
Small Cell Lung Cancer 4 99.16 Very High Very High Very High
Pancreatitis 21 98.84 Very High Very High Very High
Alcoholic Pancreatitis 3 98.16 Very High Very High Very High
Pain 18 96.68 Very High Very High Very High
Pruritus 112 96.16 Very High Very High Very High
Targeted Disruption 5 93.76 High High
Benign Prostatic Hypertrophy 2 92.80 High High
Anxiety Disorder 52 92.32 High High
Eczema 3 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum level of progastrin-releasing peptide (ProGRP) was slightly elevated.
Positive_regulation (elevated) of progastrin-releasing peptide
1) Confidence 0.70 Published 2002 Journal Hinyokika Kiyo Section Abstract Doc Link 11968736 Disease Relevance 0.54 Pain Relevance 0.09
The serum level of progastrin-releasing peptide (ProGRP) was slightly elevated.
Positive_regulation (elevated) of ProGRP
2) Confidence 0.70 Published 2002 Journal Hinyokika Kiyo Section Abstract Doc Link 11968736 Disease Relevance 0.53 Pain Relevance 0.08
The concentration of bombesin producing 50% inhibition of field stimulation (ED50) was increased following treatment with the putative M1 muscarinic antagonist, pirenzipine suggesting activation of M1 cholinergic inhibitory receptors by bombesin.
Positive_regulation (increased) of bombesin associated with antagonist
3) Confidence 0.53 Published 1984 Journal Life Sci. Section Abstract Doc Link 6548281 Disease Relevance 0.07 Pain Relevance 0.22
Therefore, activation of GRP receptor may facilitate the excitation of the interneurons and enhanced spontaneous GABAergic, but not glutamatergic neurotransmission.
Positive_regulation (activation) of GRP in interneurons associated with gabaergic
4) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2945970 Disease Relevance 0.14 Pain Relevance 0.43
Since GRP can excite interneurons, we speculated that activation of GRP receptor would affect the release of GABA in the ACC.
Positive_regulation (activation) of GRP in interneurons associated with gaba and anterior cingulate cortex
5) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.61
GRP induced significant secretion at lower concentrations (10(-11) and 10(-10) M) than were required for bombesin and GRP-(21-27) (10(-7) M).
Positive_regulation (required) of GRP
6) Confidence 0.43 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8476064 Disease Relevance 0.09 Pain Relevance 0.09
The frequency of sIPSCs was significantly increased to 140.1 ± 7.8% (n = 10, p < 0.001) and 183.4 ± 10.6% (n = 10, p < 0.001) at 300 and 1000 nM GRP, respectively (Figure 4E).
Positive_regulation (increased) of GRP
7) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.37
The mean amplitude of sIPSCs was also significantly increased at both 300 nM GRP (110.6 ± 3.9%, n = 5, p < 0.05) and 1000 nM GRP (124.8 ± 9.0%, n = 5, p < 0.01) (Figure 4E).
Positive_regulation (increased) of GRP
8) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.35
GRP induced inward currents in interneurons but small or undetectable currents in pyramidal neurons
Positive_regulation (induced) of GRP in interneurons associated with pyramidal cell
9) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.66
The mean amplitude of sIPSCs was also significantly increased at both 300 nM GRP (110.6 ± 3.9%, n = 5, p < 0.05) and 1000 nM GRP (124.8 ± 9.0%, n = 5, p < 0.01) (Figure 4E).
Positive_regulation (increased) of GRP
10) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.36
In the colon, a twofold increase in response to bombesin was observed, from 446 +/- 59 mN/cm2 (82% of the response to bethanechol) in the newborn to 862 +/- 11 mN/cm2 (29% of the response to bethanechol) in the weanling (P less than 0.05).
Positive_regulation (increase) of bombesin in colon
11) Confidence 0.40 Published 1991 Journal Gastroenterology Section Abstract Doc Link 2001835 Disease Relevance 0.08 Pain Relevance 0.12
We conclude that the direct myogenic action of GRP-10 and NMB in the esophagus is mediated mainly via NMB-preferring receptors, while GRP-preferring receptors are responsible for the contractile responses to bombesin-like peptides in feline fundus and duodenum.
Positive_regulation (action) of GRP-10 in duodenum
12) Confidence 0.34 Published 1998 Journal Peptides Section Abstract Doc Link 9533644 Disease Relevance 0 Pain Relevance 0.18
In both segments, BME shifted the GRP-10 and NMB concentration-response curves to the right, while SSocta had no effect.
Positive_regulation (shifted) of GRP-10
13) Confidence 0.34 Published 1998 Journal Peptides Section Abstract Doc Link 9533644 Disease Relevance 0 Pain Relevance 0.20
PACAP 1-38 (10(-9) M) increased substance P (SP), gastrin releasing peptide (GRP) and VIP release.
Positive_regulation (increased) of GRP associated with substance p
14) Confidence 0.32 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495686 Disease Relevance 0 Pain Relevance 0.48
PACAP 1-38 (10(-9) M) increased substance P (SP), gastrin releasing peptide (GRP) and VIP release.
Positive_regulation (increased) of gastrin releasing peptide associated with substance p
15) Confidence 0.32 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495686 Disease Relevance 0 Pain Relevance 0.48
The results show that an NEP-like enzyme on the surface of gastric muscle cells degrades and inactivates enkephalins, GRP-10 and somatostatin-14 and acts in a manner analogous to that of acetylcholinesterase in the neuromuscular junction of skeletal muscle.
Positive_regulation (inactivates) of GRP-10 in neuromuscular junction associated with somatostatin and enkephalin
16) Confidence 0.31 Published 1993 Journal Exp. Physiol. Section Abstract Doc Link 8448012 Disease Relevance 0 Pain Relevance 1.09
GRP-induced Isc increases were halved by serosal furosemide (0.3 mM) and reduced by 65% and 90% in tissue bathing solutions lacking Cl- or Cl- and HCO3-, respectively.
Positive_regulation (increases) of GRP
17) Confidence 0.24 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 3238049 Disease Relevance 0 Pain Relevance 0.13
GRPR is a G protein-coupled receptor for gastrin-releasing peptide (GRP), a bombesin-like peptide that is widely distributed in the gastrointestinal tract and central nervous system.
Positive_regulation (distributed) of bombesin-like peptide in central nervous system associated with central nervous system
18) Confidence 0.23 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950052 Disease Relevance 1.43 Pain Relevance 0.39
In contrast, in isolated islets, 4-DAMP or hexamethonium (10 or 100 microM) did not inhibit GRP (100 nM)-induced insulin secretion.
Positive_regulation (-induced) of GRP
19) Confidence 0.19 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458757 Disease Relevance 0 Pain Relevance 0.14
We conclude that the insulinotropic effect of GRP in the mouse is mediated by both direct islet effects and through activation, at the ganglionic level, of postganglionic cholinergic nerves.
Positive_regulation (mediated) of GRP in nerves
20) Confidence 0.19 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458757 Disease Relevance 0 Pain Relevance 0.14

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