INT189913

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.82
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Arid1a) intracellular (Arid1a) DNA binding (Arid1a)
Anatomy Link Frequency
brain 1
spleen 1
Arid1a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 97.16 Very High Very High Very High
Dopamine 10 61.96 Quite High
Neurotransmitter 2 50.56 Quite High
epidural 1 32.40 Quite Low
Regional anesthesia 1 31.44 Quite Low
medulla 2 16.76 Low Low
Central nervous system 2 10.68 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 167 97.68 Very High Very High Very High
Targeted Disruption 161 97.48 Very High Very High Very High
Stress 7 97.00 Very High Very High Very High
Hypersensitivity 2 96.60 Very High Very High Very High
Obesity-hypoventilation Syndrome 28 73.80 Quite High
Atelectasis 9 70.92 Quite High
Disease 26 57.28 Quite High
Death 20 50.00 Quite Low
Dilated Cardiomyopathy 5 49.72 Quite Low
Genetic Predisposition To Disease 1 45.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the phenotypes are likely caused by the specific effect of SOD2 knockdown because (1) the siRNA was expressed widely; (2) the consequences of SOD2 deficiency were observed in the transgenic mice; (3) in cells isolated from these mice the hypersensitivity to oxidative stress was corrected by the Sod2 gene that was resistant to the siRNA; (4) the phenotype typical of the SOD2-null mouse was observed when siRNA levels were increased in the bigenic 8/26 mice; and (5) levels of OSA1 and STAT1, two molecules involved in the dsRNA-induced interferon response, were unchanged.
Positive_regulation (increased) of OSA1 associated with stress, targeted disruption and hypersensitivity
1) Confidence 0.44 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.74 Pain Relevance 0
Real-time PCR analysis failed to detect an upregulation of the OSA1 and STAT1 genes in the brain and spleen tissues of PINK1 RNAi transgenic mice (Figure 4), indicating that expression of the PINK1 shRNA transgene did not induce significant interferon response.


Positive_regulation (upregulation) of OSA1 in spleen associated with targeted disruption
2) Confidence 0.41 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.23 Pain Relevance 0.08
Real-time PCR analysis failed to detect an upregulation of the OSA1 and STAT1 genes in the brain and spleen tissues of PINK1 RNAi transgenic mice (Figure 4), indicating that expression of the PINK1 shRNA transgene did not induce significant interferon response.


Positive_regulation (upregulation) of OSA1 in brain associated with targeted disruption
3) Confidence 0.14 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.23 Pain Relevance 0.08
Untreated OSA patients should be introduced to CPAP therapy before elective surgery and patients are often encouraged to bring their own machine with them for the operation.
Positive_regulation (introduced) of OSA
4) Confidence 0.12 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.61 Pain Relevance 0.10

General Comments

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