INT18992

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Context Info
Confidence 0.42
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 19.02
Pain Relevance 40.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
paw 4
neurons 4
brain 2
dorsal root 2
ventricles 1
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 117 100.00 Very High Very High Very High
Pain 84 100.00 Very High Very High Very High
Kinase C inhibitor 19 100.00 Very High Very High Very High
Thermal hyperalgesia 11 100.00 Very High Very High Very High
intrathecal 9 100.00 Very High Very High Very High
adenocard 9 100.00 Very High Very High Very High
Hyperalgesia 75 99.96 Very High Very High Very High
narcan 48 99.96 Very High Very High Very High
tetrodotoxin 8 99.92 Very High Very High Very High
Morphine 63 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 87 100.00 Very High Very High Very High
Bordatella Infection 8 100.00 Very High Very High Very High
Hypertension 6 99.68 Very High Very High Very High
Nervous System Injury 2 99.56 Very High Very High Very High
Opiate Addiction 10 99.54 Very High Very High Very High
Pain 78 99.22 Very High Very High Very High
INFLAMMATION 20 99.00 Very High Very High Very High
Neuropathic Pain 7 98.72 Very High Very High Very High
Diabetes Mellitus 41 97.36 Very High Very High Very High
Nociception 67 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main objectives of this study were to investigate the effects of deoxycorticosterone acetate (DOCA)-induced hypertension on the aortic and mesenteric vascular responses to vasodilator and vasoconstrictor agents and also to elucidate whether protein kinase C (PKC) was involved in these responses, by using chelerythrine and calphostin C, the inhibitors of protein kinase C.
Negative_regulation (inhibitors) of protein kinase associated with kinase c and hypertension
1) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15212975 Disease Relevance 0.33 Pain Relevance 0.14
The protein kinase inhibitor staurosporine and down-regulation of protein kinase C activity greatly reduced the desipramine-dependent enhancement of the frequency of tetrodotoxin-resistant spontaneous excitatory postsynaptic currents.
Negative_regulation (down-regulation) of protein kinase associated with tetrodotoxin, desipramine and kinase c
2) Confidence 0.37 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218774 Disease Relevance 0.12 Pain Relevance 1.04
Inhibition of protein kinase C with chelerythrine chloride (5 microM) depressed the osmotically-induced release of aspartate, glutamate, taurine and glycine.
Negative_regulation (Inhibition) of protein kinase associated with glutamate and kinase c
3) Confidence 0.32 Published 1998 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9877315 Disease Relevance 0.24 Pain Relevance 0.25
On the other hand, the expression of withdrawal signs precipitated by the administration of glutamate or naloxone in opioid-dependent animals was completely blocked by concomitant infusion with 1 or 10 nmol/microl/h of an inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase and protein kinase C, H-7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine].
Negative_regulation (inhibitor) of protein kinase associated with kinase c, adenocard, glutamate, narcan, opioid and withdrawal
4) Confidence 0.29 Published 1998 Journal J. Biomed. Sci. Section Abstract Doc Link 9570513 Disease Relevance 0.28 Pain Relevance 2.15
Inhibitors of protein kinase A, protein kinase C (non-selective), protein kinase G and nitric oxide synthase attenuated hyperalgesia equally in both sexes.
Negative_regulation (Inhibitors) of protein kinase associated with hyperalgesia and kinase c
5) Confidence 0.29 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927197 Disease Relevance 1.07 Pain Relevance 0.79
A defined mixture of purified gangliosides, which inhibits intracellular protein kinase C translocation and activation, decreased inflammation-induced paw withdrawal latency, and specifically decreased the activity of membrane-associated protein kinase Cbetall on the side of the spinal cord ipsilateral to the inflammation.
Negative_regulation (decreased) of protein kinase in paw associated with kinase c, inflammation, withdrawal and spinal cord
6) Confidence 0.28 Published 2001 Journal Neuroscience Section Abstract Doc Link 11440817 Disease Relevance 1.01 Pain Relevance 1.25
On the other hand, the expression of withdrawal signs precipitated by the administration of glutamate or naloxone in opioid-dependent animals was completely blocked by concomitant infusion with 1 or 10 nmol/microl/h of an inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase and protein kinase C, H-7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine].
Negative_regulation (inhibitor) of protein kinase associated with kinase c, adenocard, glutamate, narcan, opioid and withdrawal
7) Confidence 0.25 Published 1998 Journal J. Biomed. Sci. Section Abstract Doc Link 9570513 Disease Relevance 0.28 Pain Relevance 2.14
An inhibitor of protein kinase Cepsilon attenuated hyperalgesia in males and ovariectomized females, but not in normal females or in ovariectomized females with estrogen implants, whereas inhibitors of protein kinase Cdelta attenuated hyperalgesia in females but not in males.
Negative_regulation (inhibitors) of protein kinase associated with hyperalgesia
8) Confidence 0.25 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927197 Disease Relevance 1.03 Pain Relevance 0.75
An inhibitor of protein kinase Cepsilon attenuated hyperalgesia in males and ovariectomized females, but not in normal females or in ovariectomized females with estrogen implants, whereas inhibitors of protein kinase Cdelta attenuated hyperalgesia in females but not in males.
Negative_regulation (inhibitor) of protein kinase associated with hyperalgesia
9) Confidence 0.25 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927197 Disease Relevance 0.86 Pain Relevance 0.67
Tedisamil inhibits I(to), potassium current (IK), K(ATP) and the protein kinase A-activated chloride channel in ventricles as well as vascular IK and Ca(2+)-activated IK (IK((Ca))).
Negative_regulation (inhibits) of protein kinase in ventricles
10) Confidence 0.23 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11116286 Disease Relevance 0.17 Pain Relevance 0.04
Phenobarbital inhibits protein kinase C of rat brain by competitively displacing the effector of the enzyme, diacylglycerol.
Negative_regulation (inhibits) of protein kinase in brain associated with kinase c
11) Confidence 0.23 Published 1987 Journal Life Sci. Section Abstract Doc Link 3796214 Disease Relevance 0 Pain Relevance 0.15
Protein kinase inhibitors did not induce significant behavioural responses in non-dependent animals.
Negative_regulation (inhibitors) of Protein kinase
12) Confidence 0.22 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8996817 Disease Relevance 0.15 Pain Relevance 1.40
Activation of protein kinase A and C markedly enhanced the effect of GBR-12909, whereas protein kinase inhibition by H7 reduced the GBR-12909 effect.
Negative_regulation (inhibition) of protein kinase
13) Confidence 0.22 Published 2002 Journal Synapse Section Abstract Doc Link 12211084 Disease Relevance 0 Pain Relevance 0.52
The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats.
Negative_regulation (inhibitor) of protein kinase in locus coeruleus associated with glutamate, locus ceruleus, narcan, withdrawal and opioid
14) Confidence 0.21 Published 1998 Journal J. Biomed. Sci. Section Title Doc Link 9570513 Disease Relevance 0.25 Pain Relevance 1.86
Inhibitors of protein kinase A, protein kinase C (non-selective), protein kinase G and nitric oxide synthase attenuated hyperalgesia equally in both sexes.
Negative_regulation (Inhibitors) of protein kinase associated with hyperalgesia and kinase c
15) Confidence 0.21 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927197 Disease Relevance 1.06 Pain Relevance 0.79
Inhibitors of protein kinase A, protein kinase C (non-selective), protein kinase G and nitric oxide synthase attenuated hyperalgesia equally in both sexes.
Negative_regulation (Inhibitors) of protein kinase associated with hyperalgesia and kinase c
16) Confidence 0.21 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927197 Disease Relevance 1.08 Pain Relevance 0.80
Dextrorphan (an N-methyl-D-aspartate receptor antagonist), L-703,606 (an NK-1 receptor antagonist) and an antisense oligodeoxynucleotide for a selective knockdown of protein kinase Cbeta, reduced complete Freund's adjuvant-induced hyperalgesia, and reversed significant changes in the membrane activity of protein kinase CbetaII on the spinal cord section ipsilateral to the inflamed paw.
Negative_regulation (knockdown) of protein kinase in paw associated with hyperalgesia, antagonist, nmda receptor and spinal cord
17) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360284 Disease Relevance 0.68 Pain Relevance 0.83
Various protein kinase C inhibitors diminished UTP-, but not electrically, induced tritium overflow by > 70%, as did down-regulation of protein kinase C by 24 h exposure to phorbol ester. beta-Phorbol-12,13-dibutyrate and dioctanoylglycerol caused concentration-dependent increases in [(3)H] outflow of up to 6% of total radioactivity, and the secretagogue actions of these agents were reduced in the presence of protein kinase C inhibitors and in neurons pretreated with phorbol ester.
Negative_regulation (regulation) of protein kinase in neurons associated with kinase c and kinase c inhibitor
18) Confidence 0.16 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11331416 Disease Relevance 0 Pain Relevance 0.37
An adenylyl cyclase inhibitor (SQ 22536) and a protein kinase A inhibitor (H-89) decreased Ca2+ current amplitude.
Negative_regulation (inhibitor) of protein kinase
19) Confidence 0.14 Published 2008 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 18389010 Disease Relevance 0 Pain Relevance 0.49
An adenylyl cyclase inhibitor (SQ 22536) and a protein kinase A inhibitor (H-89) decreased Ca2+ current amplitude.
Negative_regulation (inhibitor) of protein kinase
20) Confidence 0.14 Published 2008 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 18389010 Disease Relevance 0 Pain Relevance 0.50

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