INT189927

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 9.03
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Arid1a) intracellular (Arid1a) DNA binding (Arid1a)
Anatomy Link Frequency
liver 2
spleen 2
heart 2
Arid1a (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 11 90.84 High High
anesthesia 37 90.72 High High
Dopamine 5 70.24 Quite High
imagery 4 63.28 Quite High
Inflammation 48 59.96 Quite High
Neurotransmitter 1 35.84 Quite Low
cva 8 34.08 Quite Low
medulla 1 25.04 Quite Low
Central nervous system 1 18.96 Low Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 503 100.00 Very High Very High Very High
Obesity-hypoventilation Syndrome 112 100.00 Very High Very High Very High
Hypercapnia 40 100.00 Very High Very High Very High
Obesity 668 99.68 Very High Very High Very High
Stress 43 96.12 Very High Very High Very High
Hypersensitivity 14 95.72 Very High Very High Very High
Weight Loss 28 95.66 Very High Very High Very High
Morbid Obesity 12 92.48 High High
Disease 73 88.88 High High
Dilated Cardiomyopathy 35 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Neg (no) Gene_expression (response) of OSA1 in spleen associated with targeted disruption
1) Confidence 0.59 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.71 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Gene_expression (expression) of OSA1 in heart associated with targeted disruption
2) Confidence 0.59 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
To exclude this possibility, we examined the expression of oligoadenylate synthetase 1 (OSA1) and signal transducer and activator of transcription 1 (STAT1), which are known to be induced by some shRNA 29-31.
Spec (examined) Gene_expression (expression) of OSA1
3) Confidence 0.53 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.14 Pain Relevance 0.07
Taken together, the phenotypes are likely caused by the specific effect of SOD2 knockdown because (1) the siRNA was expressed widely; (2) the consequences of SOD2 deficiency were observed in the transgenic mice; (3) in cells isolated from these mice the hypersensitivity to oxidative stress was corrected by the Sod2 gene that was resistant to the siRNA; (4) the phenotype typical of the SOD2-null mouse was observed when siRNA levels were increased in the bigenic 8/26 mice; and (5) levels of OSA1 and STAT1, two molecules involved in the dsRNA-induced interferon response, were unchanged.
Gene_expression (levels) of OSA1 associated with stress, targeted disruption and hypersensitivity
4) Confidence 0.53 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.74 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Neg (no) Gene_expression (response) of OSA1 in heart associated with targeted disruption
5) Confidence 0.20 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.71 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Neg (no) Gene_expression (response) of OSA1 in liver associated with targeted disruption
6) Confidence 0.20 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.71 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Gene_expression (expression) of OSA1 in spleen associated with targeted disruption
7) Confidence 0.20 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Gene_expression (expression) of OSA1 in liver associated with targeted disruption
8) Confidence 0.20 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
However, two patients were found to have an increase in their AHI despite significant weight loss.26 A meta-analysis by Greenburg et al39 representing 342 patients in the year 2009, showed similar results with bariatric surgery significantly reducing AHI, however, to a mean value still consistent with moderately severe OSA.39
Gene_expression (severe) of OSA associated with weight loss
9) Confidence 0.16 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.01 Pain Relevance 0
At 1 year follow-up, despite a mean BMI reduction of 18.4 kg/m2 and an average drop in AHI of 23.4 events per hour, only one patient experienced complete resolution of OSA.
Gene_expression (resolution) of OSA associated with obesity
10) Confidence 0.16 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.45 Pain Relevance 0
Furthermore, in OSA with chronic hypercapnia, the leptin levels were even higher.44 Finally, Chin et al45 demonstrated a noticeable reduction in leptin levels following CPAP treatment.45 All these studies propose an important role of leptin and highlight the potential significance of the development of leptin resistance in obesity and OHS.
Gene_expression (were) of OSA associated with obesity, hypercapnia and obesity-hypoventilation syndrome
11) Confidence 0.16 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.46 Pain Relevance 0.05
In particular, OSA and OHS should always be considered in the obese patient undergoing assessment for surgery.27
Gene_expression (considered) of OSA associated with obesity and obesity-hypoventilation syndrome
12) Confidence 0.16 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.10 Pain Relevance 0.32

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