INT189943

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
thyroid 1
cervix 1
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 54 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 20 99.86 Very High Very High Very High
Hyperglycemia 6 99.16 Very High Very High Very High
Apoptosis 112 97.48 Very High Very High Very High
Metastasis 84 96.80 Very High Very High Very High
Cancer 570 95.12 Very High Very High Very High
Targeted Disruption 162 93.56 High High
Lung Cancer 44 92.80 High High
Non-small-cell Lung Cancer 26 92.32 High High
Death 13 91.96 High High
Diabetes Mellitus 6 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Funabiki et al. [43] showed that in fission yeast, the loss of securin completely blocked chromosome segregation and the completion of mitosis and is therefore lethal.
Negative_regulation (loss) of securin
1) Confidence 0.53 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.33 Pain Relevance 0
Much has been investigated and is known about the upregulation of PTTG1, downregulation of PTTG of keen interest at this point.
Negative_regulation (downregulation) of PTTG
2) Confidence 0.46 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.08 Pain Relevance 0
In cervix carcinoma cells inhibition of PTTG-1 using antisense-ODNs leads to growth inhibition and increased apoptosis [21].
Negative_regulation (inhibition) of PTTG-1 in cervix associated with carcinoma and apoptosis
3) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.46 Pain Relevance 0
Thus, it is likely that the other mechanisms compensated for the loss of securin and its function in the cell cycle.
Negative_regulation (loss) of securin
4) Confidence 0.39 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.63 Pain Relevance 0
We [18] transfected H1299 cells with PTTG1 siRNA duplex and found that PTTG1 mRNA was almost completely depleted within a day or two in comparison to untransfected or control cells.
Negative_regulation (depleted) of PTTG1 mRNA
5) Confidence 0.39 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.90 Pain Relevance 0
The time lapse experiments and immunofluorescence microscopy experiments showed that the human cells lacking securin failed to have chromatid separation.
Negative_regulation (lacking) of securin
6) Confidence 0.39 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.68 Pain Relevance 0
Though the IGF-1 and thyroid hormone levels were normal in these mice, some additional non-genetic factors may have contributed to hyperglycemia development in these mice in addition to PTTG loss.
Negative_regulation (loss) of PTTG in thyroid associated with hyperglycemia
7) Confidence 0.34 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.71 Pain Relevance 0

General Comments

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