INT189944

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.53
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
lung 4
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 18 5.00 Very Low Very Low Very Low
palliative 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 68 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 78 99.34 Very High Very High Very High
Death 7 99.16 Very High Very High Very High
Cancer 318 98.84 Very High Very High Very High
Breast Cancer 13 98.48 Very High Very High Very High
Apoptosis 48 96.96 Very High Very High Very High
Repression 6 92.00 High High
Carcinoma 12 90.80 High High
Targeted Disruption 54 89.12 High High
Chromosomal Instability 11 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With regard to the degree of PTTG-1 expression low PTTG-1 staining intensity was found in 52 cases (57.1%) and strong cytoplasmatic PTTG-1 staining intensity was found in 37 cases (40.7%).
Negative_regulation (degree) of Gene_expression (expression) of PTTG-1
1) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.86 Pain Relevance 0
Further, PTTG-1 overexpression in the human lung cancer cell line A549 inhibited the cell growth via activation of p21 [20].
Negative_regulation (inhibited) of Gene_expression (overexpression) of PTTG-1 in lung associated with lung cancer
2) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.29 Pain Relevance 0
For example, p53 mediated cell death of NSCLC lung cancer cell line H1299 was impeded by PTTG-1 expression by blocking the specific binding of p53 to DNA and inhibiting the transcriptional function of p53 [14].
Negative_regulation (impeded) of Gene_expression (expression) of PTTG-1 in lung associated with lung cancer, non-small-cell lung cancer and death
3) Confidence 0.42 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.35 Pain Relevance 0
The DNA damage induced by doxorubicin and bleomycin activated p53 and thereby suppressed expression of securin.
Negative_regulation (suppressed) of Gene_expression (expression) of securin
4) Confidence 0.39 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.30 Pain Relevance 0
In addition, they showed that the deletion of securin blocked anaphase.
Negative_regulation (blocked) of Gene_expression (deletion) of securin
5) Confidence 0.39 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.72 Pain Relevance 0

General Comments

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