INT189946

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 23.72
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
lymph node 6
leukocytes 5
astrocytes 4
lung 4
pituitary 2
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 24 87.36 High High
addiction 12 85.96 High High
Pain 8 73.20 Quite High
headache 1 70.12 Quite High
Central nervous system 8 53.76 Quite High
metalloproteinase 72 39.12 Quite Low
Kinase C 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 179 100.00 Very High Very High Very High
Malignant Neoplastic Disease 61 100.00 Very High Very High Very High
Cancer 1275 99.98 Very High Very High Very High
Adenoma 20 99.74 Very High Very High Very High
Lung Cancer 272 99.48 Very High Very High Very High
Chromosomal Instability 44 99.24 Very High Very High Very High
Non-small-cell Lung Cancer 312 99.08 Very High Very High Very High
Adenocarcinoma 52 98.88 Very High Very High Very High
Small Cell Lung Cancer 228 98.56 Very High Very High Very High
Metastasis 240 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This would be in line with our results showing that increased PTTG-1 expression was significantly correlated to clinical and pathological markers indicating an unfavourable outcome for patients with NSCLC such as extensive lymph node metastases, presence of distant metastases and increased LDH levels.
Positive_regulation (increased) of Gene_expression (expression) of PTTG-1 in lymph node associated with non-small-cell lung cancer and metastasis
1) Confidence 0.68 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.42 Pain Relevance 0
Further, several other studies implicate that PTTG-1 overexpression was associated to chromosomal instability, increased distant metastases, increased neoangiogenesis and invasiveness of the tumor [5,6,22].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG-1 associated with chromosomal instability, cancer and metastasis
2) Confidence 0.68 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.38 Pain Relevance 0
These features, induced by PTTG-1 overexpression, would rather cause a more aggressive tumor phenotype.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG-1 associated with cancer
3) Confidence 0.68 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.43 Pain Relevance 0
Further, PTTG-1 overexpression in the human lung cancer cell line A549 inhibited the cell growth via activation of p21 [20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG-1 in lung associated with lung cancer
4) Confidence 0.68 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.22 Pain Relevance 0
On one hand, recent studies indicate that overexpression of PTTG-1 was associated to induce p53 independent and p53-dependent apoptosis [13,19] when looking at breast cancer cells or kidney cell lines.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG-1 in kidney associated with breast cancer and apoptosis
5) Confidence 0.68 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.18 Pain Relevance 0
Next, the prognostic relevance of PTTG-1 expression on survival of the patients was examined.
Positive_regulation (relevance) of Gene_expression (expression) of PTTG-1
6) Confidence 0.49 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.17 Pain Relevance 0
As a result PTTG-1 expression was negatively correlated with survival.
Positive_regulation (result) of Gene_expression (expression) of PTTG-1
7) Confidence 0.49 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.74 Pain Relevance 0.05
When comparing patients group with strong PTTG-1 expression versus negative/low PTTG-1 expression statistically significant differences were noticed with respect to gender (p = 0.04), LDH level (p = 0.005), leucocyte count (p = 0.016) and tumor stage (p = 0.021).
Positive_regulation (negative) of Gene_expression (expression) of PTTG-1 in leucocyte associated with cancer
8) Confidence 0.49 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.34 Pain Relevance 0.09
From their analyses, these investigators found a direct correlation between PTTG1 mRNA overexpression and lymph node infiltration.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG1 mRNA in lymph node
9) Confidence 0.46 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.62 Pain Relevance 0.07
These results underline that a high expression of PTTG-1 plays an important role in biology of lung cancer, which differs in SCLC and NSCLC.
Positive_regulation (expression) of Gene_expression (expression) of PTTG-1 in lung associated with lung cancer, non-small-cell lung cancer and small cell lung cancer
10) Confidence 0.46 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.34 Pain Relevance 0.04
Further, PTTG-1 expression was associated with a more aggressive NSCLC phenotype with an advanced pathological stage, extensive lymph node metastases, distant metastases and increased LDH level.
Positive_regulation (associated) of Gene_expression (expression) of PTTG-1 in lymph node associated with non-small-cell lung cancer and metastasis
11) Confidence 0.46 Published 2006 Journal J Carcinog Section Abstract Doc Link PMC1360069 Disease Relevance 1.71 Pain Relevance 0
We showed that 64% of SCLC tumors and 97.8% of NSCLC tumors examined by immunohistochemistry were positive for PTTG-1 expression.
Positive_regulation (positive) of Gene_expression (expression) of PTTG-1 associated with non-small-cell lung cancer, cancer and small cell lung cancer
12) Confidence 0.46 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.09 Pain Relevance 0
gene [4], and many functional adenomas present the overexpression of a recently discovered powerful transforming gene, PTTG, which is able to exert strong transforming effects both in vitro and in vivo [5].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG associated with adenoma
13) Confidence 0.43 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 1.17 Pain Relevance 0.07
Subsequently, the human homologue of PTTG was identified and shown to be overexpressed in Jurkat T cells and leukocytes from patients with myelodysplastic syndromes [9].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PTTG in leukocytes associated with myelodysplastic syndromes
14) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.11 Pain Relevance 0.03
PTTG1 mRNA expression and protein levels were increased in malignant astrocytes when treated with IGF-I or insulin, whereas in rat embryonic astrocytes, PTTG1 expression and protein levels increased only when cells were exposed to IGF-I.
Positive_regulation (increased) of Gene_expression (expression) of PTTG1 mRNA in astrocytes associated with malignant neoplastic disease
15) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.45 Pain Relevance 0
PTTG1 mRNA expression and protein levels were increased in malignant astrocytes when treated with IGF-I or insulin, whereas in rat embryonic astrocytes, PTTG1 expression and protein levels increased only when cells were exposed to IGF-I.
Positive_regulation (increased) of Gene_expression (expression) of PTTG1 mRNA in astrocytes associated with malignant neoplastic disease
16) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.46 Pain Relevance 0
Kakar and Jennes [12] and Hamid et al. [70] showed that overexpression of PTTG in NIH3T3 as well as the human embryonic kidney cell line HEK 293 resulted in increased cell proliferation, induction of cellular transformation, and development of tumors in nude mice, suggesting an oncogenic function of PTTG in human tumorigenesis.


Positive_regulation (overexpression) of Gene_expression (overexpression) of PTTG in embryonic kidney associated with cancer
17) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.87 Pain Relevance 0
Overexpression of PTTG in vitro induces cellular transformation and development of tumors in nude mice.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PTTG associated with cancer
18) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Abstract Doc Link PMC2584053 Disease Relevance 0.93 Pain Relevance 0
Proliferating cancer cells and most tumors express high levels of PTTG.
Positive_regulation (levels) of Gene_expression (express) of PTTG associated with cancer
19) Confidence 0.42 Published 2008 Journal J Ovarian Res Section Abstract Doc Link PMC2584053 Disease Relevance 0.92 Pain Relevance 0
PTTG-1 (pituitary tumor transforming gene) is a novel oncogene that is overexpressed in tumors, such as pituitary adenoma, breast and gastrointestinal cancers as well as in leukemia.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PTTG-1 in pituitary associated with leukemia, cancer, pituitary cancer and gastrointestinal neoplasms
20) Confidence 0.40 Published 2006 Journal J Carcinog Section Abstract Doc Link PMC1360069 Disease Relevance 1.08 Pain Relevance 0

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