INT189947

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 7.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
lung 1
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 27 5.00 Very Low Very Low Very Low
palliative 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 51 100.00 Very High Very High Very High
Cancer 405 99.84 Very High Very High Very High
Lung Cancer 72 99.76 Very High Very High Very High
Small Cell Lung Cancer 57 99.28 Very High Very High Very High
Metastasis 72 98.72 Very High Very High Very High
Apoptosis 66 91.40 High High
Gastrointestinal Neoplasms 3 90.76 High High
Leukemia 12 89.20 High High
Non-small-cell Lung Cancer 78 82.08 Quite High
Ovarian Cancer 48 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand down regulation of PTTG in cancer results in suppression of tumor growth and angiogenesis, suggesting that PTTG may serve as an important target gene for the treatment of cancer.
Regulation (regulation) of PTTG associated with cancer
1) Confidence 0.49 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.39 Pain Relevance 0
The intensity of PTTG-1 staining as well as the proportion of PTTG-1 positive cells within a tumor was taken into consideration for univariate and multivariate survival analyses.


Regulation (intensity) of PTTG-1 associated with cancer
2) Confidence 0.44 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.19 Pain Relevance 0
The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer

Background

Regulation (influence) of PTTG-1 in lung associated with lung cancer and pituitary cancer
3) Confidence 0.27 Published 2006 Journal J Carcinog Section Title Doc Link PMC1360069 Disease Relevance 1.52 Pain Relevance 0
Prognostic value of PTTG-1 in patients with SCLC using Kaplan-Meier survival curves
Regulation (value) of PTTG-1 associated with small cell lung cancer
4) Confidence 0.27 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.66 Pain Relevance 0
Up regulation of PTTG increases cell proliferation, induces cellular transformation and promotes tumor development in nude mice.
Regulation (regulation) of PTTG associated with cancer
5) Confidence 0.22 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.43 Pain Relevance 0
Recent studies show that down regulation of PTTG in tumor cell lines and tumors in vivo results in suppression of tumor growth, suggesting its important role in tumorigenesis.
Regulation (regulation) of PTTG associated with cancer
6) Confidence 0.22 Published 2008 Journal J Ovarian Res Section Abstract Doc Link PMC2584053 Disease Relevance 1.00 Pain Relevance 0

General Comments

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