INT189948

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2008
Negated 7
Speculated 1
Reported most in Body
Documents 106
Total Number 107
Disease Relevance 104.68
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Pttg1) chromosome organization (Pttg1) chromosome segregation (Pttg1)
nucleus (Pttg1) cell cycle (Pttg1) cell division (Pttg1)
Anatomy Link Frequency
lung 12
pituitary 7
lymph node 5
leucocyte 4
embryos 1
Pttg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
palliative 170 98.40 Very High Very High Very High
addiction 89 98.28 Very High Very High Very High
Pain 15 81.20 Quite High
Dopamine 30 74.84 Quite High
headache 2 70.12 Quite High
Central nervous system 15 53.76 Quite High
metalloproteinase 135 39.12 Quite Low
Disease Link Frequency Relevance Heat
Cancer 5688 100.00 Very High Very High Very High
Pituitary Cancer 592 100.00 Very High Very High Very High
INFLAMMATION 21 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 2210 99.96 Very High Very High Very High
Lung Cancer 1760 99.96 Very High Very High Very High
Small Cell Lung Cancer 1615 99.96 Very High Very High Very High
Adenoma 37 99.74 Very High Very High Very High
Breast Cancer 164 99.24 Very High Very High Very High
Chromosomal Instability 145 99.24 Very High Very High Very High
Hyperglycemia 15 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with negative or low expression of PTTG-1 had a significant (p = 0.0291) shorter mean survival of 265 ± 18 days compared with 379 ± 66 days for those patients with strong PTTG-1 expression (Figure 3B).
Gene_expression (expression) of PTTG-1
1) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.39 Pain Relevance 0
Of notice, beyond 300 days, a significant improved survival rate was observed for those patients with strong PTTG-1 expression compared to those with no or low PTTG-1 expression.
Gene_expression (expression) of PTTG-1
2) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.34 Pain Relevance 0
As a result, the staining intensity of PTTG-1 expression (p = 0.047), tumor stage (p = 0,051), performance status (p = 0.015), LDH level (p = 0.001) and hemoglobin level (p= 0.011) were identified as independent prognostic parameters by the Cox regression modell (Table 3).
Gene_expression (expression) of PTTG-1 associated with cancer
3) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.77 Pain Relevance 0
On one hand, recent studies indicate that overexpression of PTTG-1 was associated to induce p53 independent and p53-dependent apoptosis [13,19] when looking at breast cancer cells or kidney cell lines.
Gene_expression (overexpression) of PTTG-1 in kidney associated with breast cancer and apoptosis
4) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.18 Pain Relevance 0
The Kaplan-Meier survival analysis with log rank test was used to compare clinical parameters with PTTG-1 expression.
Gene_expression (expression) of PTTG-1
5) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.41 Pain Relevance 0
As a result PTTG-1 expression was negatively correlated with survival.
Gene_expression (expression) of PTTG-1
6) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.73 Pain Relevance 0.05
In line with our results a PTTG-1 expression was observed in 9 out of 10 primary adenocarcinomas of the lung using immunohistochemial methods [17].
Gene_expression (expression) of PTTG-1 in lung associated with adenocarcinoma
7) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.18 Pain Relevance 0
We found that a strong expression of PTTG-1 in SCLC was associated with a significant improved outcome for patients.
Gene_expression (expression) of PTTG-1 associated with small cell lung cancer
8) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.48 Pain Relevance 0.05
Patients with strong PTTG-1 expression had an unfavourable prognosis showing a mean survival of 306 ± 58 days compared with patients with PTTG-1 low or PTTG-1 negative stainings with a mean survival of 463 ± 55 days (p = 0.0386; Figure 5A).
Gene_expression (expression) of PTTG-1
9) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.70 Pain Relevance 0.06
Next, the prognostic relevance of PTTG-1 expression on survival of the patients was examined.
Gene_expression (expression) of PTTG-1
10) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.17 Pain Relevance 0
50% PTTG-1 expression (including negative cases) and tumors with > 50% of PTTG-1 expression were compared.
Gene_expression (expression) of PTTG-1 associated with cancer
11) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.68 Pain Relevance 0
Looking at the subgroup of patients in stage IIIB and IV (n = 76) receiving palliative chemotherapy, a significant difference on survival (p = 0.0229) with regard to PTTG-1 expression was observed again (Figure 5B).
Gene_expression (expression) of PTTG-1 associated with palliative
12) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.36 Pain Relevance 0.10
Patients with negative or low expression of PTTG-1 had a significant (p = 0.0291) shorter mean survival of 265 ± 18 days compared with 379 ± 66 days for those patients with strong PTTG-1 expression (Figure 3B).
Gene_expression (expression) of PTTG-1
13) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.58 Pain Relevance 0
The third group showed no immunohistochemical evidence of PTTG-1 expression.
Gene_expression (expression) of PTTG-1
14) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.23 Pain Relevance 0
With regard to the degree of PTTG-1 expression low PTTG-1 staining intensity was found in 52 cases (57.1%) and strong cytoplasmatic PTTG-1 staining intensity was found in 37 cases (40.7%).
Gene_expression (expression) of PTTG-1
15) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.86 Pain Relevance 0
This would be in line with our results showing that increased PTTG-1 expression was significantly correlated to clinical and pathological markers indicating an unfavourable outcome for patients with NSCLC such as extensive lymph node metastases, presence of distant metastases and increased LDH levels.
Gene_expression (expression) of PTTG-1 in lymph node associated with non-small-cell lung cancer and metastasis
16) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.41 Pain Relevance 0
Further, several other studies implicate that PTTG-1 overexpression was associated to chromosomal instability, increased distant metastases, increased neoangiogenesis and invasiveness of the tumor [5,6,22].
Gene_expression (overexpression) of PTTG-1 associated with chromosomal instability, cancer and metastasis
17) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.38 Pain Relevance 0
Performing RT-PCR for the detection of PTTG-1 mRNA Honda et al. detected PTTG-1 expression in 12 out of 14 NSCLCs.
Gene_expression (expression) of PTTG-1
18) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 1.18 Pain Relevance 0
Next, the proportion of PTTG-1 expression was correlated to survival of the SCLC patients.
Gene_expression (expression) of PTTG-1 associated with small cell lung cancer
19) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.60 Pain Relevance 0
The proportion of positive cells was determined semiquantitatively: (I) none, (II) between 1% and 50%, (III) between 51% and 75%, and (IV) more than 75% of the tumor cells with PTTG-1 expression.
Gene_expression (expression) of PTTG-1 associated with cancer
20) Confidence 0.76 Published 2006 Journal J Carcinog Section Body Doc Link PMC1360069 Disease Relevance 0.23 Pain Relevance 0

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