INT18995

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 14.46
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
T-cell 3
macrophages 1
B16-F1 1
brain 1
bladder 1
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 61 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Opioid 7 99.98 Very High Very High Very High
opiate 2 99.98 Very High Very High Very High
metalloproteinase 71 99.96 Very High Very High Very High
melanocortin 1 receptor 2 99.96 Very High Very High Very High
opioid receptor 6 99.64 Very High Very High Very High
Kinase C 7 98.44 Very High Very High Very High
spinal inflammation 4 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 54 100.00 Very High Very High Very High
Thalassemia 7 100.00 Very High Very High Very High
Skin Cancer 6 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 5 100.00 Very High Very High Very High
Sickle Cell Anemia 2 100.00 Very High Very High Very High
Adhesions 13 99.96 Very High Very High Very High
Carcinoma 6 99.92 Very High Very High Very High
Recurrence 2 99.90 Very High Very High Very High
Nicotine Addiction 184 99.76 Very High Very High Very High
Solid Tumor 2 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-induced nuclear factor of activated T-cell (NFAT) binding was assayed with the electromobility shift assay in Jurkat T cells.
NFAT Binding (binding) of in T-cell
1) Confidence 0.47 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
Morphine-induced nuclear factor of activated T-cell (NFAT) binding was assayed with the electromobility shift assay in Jurkat T cells.
cell Binding (binding) of in T-cell
2) Confidence 0.47 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
It has previously been reported that sickle reticulocytes express the alpha 4 beta 1 integrin receptor and bind to cytokine-activated endothelium via an alpha 4 beta 1/vascular-cell adhesion molecule-1 (VCAM-1) interaction.
cell Binding (bind) of in endothelium associated with adhesions and cytokine
3) Confidence 0.47 Published 1996 Journal Blood Section Abstract Doc Link 8943872 Disease Relevance 0.45 Pain Relevance 0.14
For this research the author utilized a frequency-to-voltage converter (FVC) as an analog calculational element to simulate the effects of drug binding to neural cell membrane receptors.
cell Binding (binding) of in neural
4) Confidence 0.47 Published 2007 Journal Biomed Sci Instrum Section Abstract Doc Link 17487094 Disease Relevance 0.22 Pain Relevance 0.38
These proline-rich repeats allow CEase to bind to membrane-associated heparin, and it has been suggested that this may facilitate cholesterol transport [26].
CEase Binding (bind) of
5) Confidence 0.42 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0 Pain Relevance 0
Use of recombinant human erythropoietin to enhance autologous blood donation in a patient with multiple red cell allo-antibodies and the anemia of chronic disease.
cell Binding (patient) of in blood associated with anaemia and chronic disease
6) Confidence 0.36 Published 1991 Journal Am. J. Med. Section Title Doc Link 2003523 Disease Relevance 0.54 Pain Relevance 0.21
Lupus enteritis: clinical characteristics, risk factor for relapse and association with anti-endothelial cell antibody.
cell Binding (association) of in endothelial cell associated with enteritis, systemic lupus erythematosus and recurrence
7) Confidence 0.36 Published 2007 Journal Lupus Section Title Doc Link 17895303 Disease Relevance 1.57 Pain Relevance 0.16
In vitro, all three peptides were more potent ligands of the mouse B16-F1 melanoma cell melanocortin-1 receptor (MC1-R) than DOTA-NAPamide, which served as standard.
cell Binding (ligands) of in B16-F1 associated with melanocortin 1 receptor and skin cancer
8) Confidence 0.36 Published 2007 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 18097939 Disease Relevance 0.54 Pain Relevance 0.18
Some of the abnormalities found in bladder epithelial cells from IC/PBS patients have been shown to be induced in normal cells by an antiproliferative factor from IC/PBS bladder epithelial cells that binds to a functional cell membrane receptor (CKAP4/p63).
cell Binding (binds) of in bladder associated with congenital anomalies
9) Confidence 0.36 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18602988 Disease Relevance 0.46 Pain Relevance 0.50
OBJECTIVE: To investigate the association of killer cell immunoglobulin-like receptors (KIR) genotype and haplotype with ankylosing spondylitis (AS).
cell Binding (association) of associated with spinal inflammation
10) Confidence 0.36 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19489269 Disease Relevance 0.17 Pain Relevance 0.17
Desmoid tumors (aggressive fibromatosis) are rare neoplastic tumors that may occur sporadically or in association with familial adenomatous polyposis (FAP).
FAP Binding (association) of associated with cancer, familial adenomatous polyposis and desmoid disease
11) Confidence 0.36 Published 2006 Journal Curr Treat Options Oncol Section Abstract Doc Link 17032556 Disease Relevance 1.44 Pain Relevance 0
The cardiac differentiation of embryonic stem (ES) cells was found to involve prodynorphin gene and dynorphin B expression and was associated with the interaction of secreted dynorphin B with cell surface opioid receptors coupled with protein kinase C (PKC) signaling and complex subcellular redistribution patterning of selected PKC isozymes.
cell Binding (interaction) of in stem associated with kinase c, dynorphin and opioid receptor
12) Confidence 0.36 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623878 Disease Relevance 0 Pain Relevance 0.63
Interactions of full and partial agonists with HT29 cell alpha 2-adrenoceptor: comparative study of [3H]UK-14,304 and [3H]clonidine binding.
cell Binding (Interactions) of associated with agonist and clonidine
13) Confidence 0.36 Published 1989 Journal Mol. Pharmacol. Section Title Doc Link 2564632 Disease Relevance 0 Pain Relevance 0.53
Opiate use in humans is associated with a reduction in the number of circulating T-lymphocytes and in their ability to undergo transformation, probably resulting from opiate binding to T-cell antigens.
cell Binding (binding) of in T-lymphocytes associated with opiate
14) Confidence 0.36 Published 1987 Journal Adv Alcohol Subst Abuse Section Abstract Doc Link 3329450 Disease Relevance 0.13 Pain Relevance 0.40
Oligodeoxyribonucleotide (oligo) primers derived from rat opioid-binding cell adhesion molecule (OBCAM)-encoding cDNA sequence were used to amplify a 403-bp fragment from a human brain cDNA library using the polymerase chain reaction (PCR).
cell Binding (binding) of in brain associated with opioid and adhesions
15) Confidence 0.35 Published 1995 Journal Gene Section Abstract Doc Link 7721093 Disease Relevance 0.31 Pain Relevance 0.17
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM).
cell Binding (binding) of associated with opioid and adhesions
16) Confidence 0.35 Published 1995 Journal Gene Section Title Doc Link 7721093 Disease Relevance 0.36 Pain Relevance 0.20
The interaction of alpha thalassaemia and sickle cell-beta zero thalassaemia.
cell Binding (interaction) of associated with sickle cell anemia and thalassemia
17) Confidence 0.35 Published 1988 Journal Br. J. Haematol. Section Title Doc Link 3219294 Disease Relevance 1.00 Pain Relevance 0.07
Multivariate logistic regression found pediatric FAP to be most closely associated with maternal history of anxiety and depression (adjusted OR, 6.1; 95% CI, 1.8-20.8).
FAP Binding (associated) of
18) Confidence 0.35 Published 2007 Journal Arch Pediatr Adolesc Med Section Body Doc Link 17283297 Disease Relevance 0.05 Pain Relevance 0
It may well be possible, that one may affect tumour invasion and metastasis by inhibiting protease action of solid tumours by disturbing the binding of proteases to tumour cell surface receptors.
cell Binding (binding) of associated with cancer, solid tumor and metastasis
19) Confidence 0.35 Published 1991 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 2040418 Disease Relevance 1.18 Pain Relevance 0.08
'Healthy' smokers had higher number of BAL MMP-12+-macrophages, than never-smokers supporting the fact of smoking impact in MMP-12 expression.
BAL Neg (never) Binding (number) of in macrophages associated with nicotine addiction and metalloproteinase
20) Confidence 0.14 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.85 Pain Relevance 0.53

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