INT189953

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 6.45
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTTG1) mitosis (PTTG1) chromosome organization (PTTG1)
chromosome segregation (PTTG1) nucleus (PTTG1) cell division (PTTG1)
Anatomy Link Frequency
pituitary 1
platelet 1
lung 1
PTTG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 54 84.00 Quite High
Kinase C 6 83.04 Quite High
Pain 6 50.84 Quite High
Central nervous system 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 82 100.00 Very High Very High Very High
Cancer 570 99.84 Very High Very High Very High
Metastasis 84 99.30 Very High Very High Very High
Lung Cancer 44 98.44 Very High Very High Very High
Ovarian Cancer 96 97.60 Very High Very High Very High
Thrombocytopenia 6 95.60 Very High Very High Very High
Adenocarcinoma 15 94.80 High High
Hyperplasia 30 94.72 High High
Gastrointestinal Neoplasms 1 90.44 High High
Leukemia 14 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results, the investigators suggested that the PTTG1 disruption caused cell cycle and chromosomal changes in PTTG1-abundant tissues in a tissue-specific manner and that PTTG1 is involved in spermatogenesis and platelet formation.
Regulation (changes) of PTTG1 in platelet
1) Confidence 0.18 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.60 Pain Relevance 0
To understand the mechanism of PTTG1 in angiogenesis and metastasis, Malik and Kakar [80] studied the regulation of MMPs by PTTG1.
Regulation (regulation) of PTTG1 associated with metastasis
2) Confidence 0.18 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.43 Pain Relevance 0.17
Voltides et al. [62] showed that PTTG1 is a target for EGFR-mediated paracrine regulation of pituitary cell growth.
Regulation (target) of PTTG1 in pituitary
3) Confidence 0.11 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.52 Pain Relevance 0
Pei [54] identified the downstream targets of the PTTG1 protein.
Regulation (targets) of PTTG1
4) Confidence 0.11 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.47 Pain Relevance 0.04
Even though these experiments did not show direct evidence that the PTTG1 protein binds to the bFGF promoter, the reporter gene assay showed that there is a direct or indirect role of PTTG1 protein and PBF on bFGF transcriptional regulation.
Regulation (regulation) of PTTG1
5) Confidence 0.11 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.49 Pain Relevance 0.04
Taken together, these findings strongly suggest that down regulation of PTTG1 in cancer results in suppression of tumor growth and progression.
Regulation (regulation) of PTTG1 associated with cancer
6) Confidence 0.11 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.43 Pain Relevance 0
The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer

Background

Regulation (influence) of tumor transforming gene-1 in lung associated with lung cancer and pituitary cancer
7) Confidence 0.06 Published 2006 Journal J Carcinog Section Title Doc Link PMC1360069 Disease Relevance 1.51 Pain Relevance 0

General Comments

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