INT189960

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 20
Disease Relevance 17.54
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (SENP8)
Anatomy Link Frequency
shell 1
NK cells 1
Raji 1
SENP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 72 99.86 Very High Very High Very High
cytokine 86 98.52 Very High Very High Very High
cva 45 84.20 Quite High
headache 20 79.84 Quite High
alcohol 12 63.52 Quite High
abdominal pain 24 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 839 100.00 Very High Very High Very High
Fever 97 99.98 Very High Very High Very High
Viral Meningitis 274 99.82 Very High Very High Very High
Dengue Hemorrhagic Fever 876 99.50 Very High Very High Very High
Dengue 863 99.02 Very High Very High Very High
Pleural Effusion 42 93.00 High High
Hepatitis C Virus Infection 28 91.16 High High
Mycobacterial Infection 48 90.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 52 89.44 High High
Facial Paralysis 20 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Den-2 was detected only in one case.


Gene_expression (detected) of Den-2
1) Confidence 0.54 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 1.12 Pain Relevance 0.08
No Den-2 was detected in this group.


Gene_expression (detected) of Den-2
2) Confidence 0.54 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 1.23 Pain Relevance 0
Using a cytospin system (Auto smear, CF-12DE, SAKURA, Japan) three smears were made on separate glass slides from each of the 50 specimens, one each for JE, WN and Den-2 virus respectively. 150 ?
Gene_expression (virus) of Den-2 associated with viral meningitis
3) Confidence 0.41 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 0.71 Pain Relevance 0
l of the specimen was inoculated into each of these shell vials 1,2 & 3 that were later stained by IIF technique for JE, WN and Den-2 viruses respectively.
Gene_expression (viruses) of Den-2 in shell associated with viral meningitis
4) Confidence 0.41 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 0.45 Pain Relevance 0
JEV was positive in 19 (18%) of cases followed by 9 (18%) WNV and Den-2 virus (one case)

Distribution of JE, WN and Den-2 viruses among the different age and sex groups

Gene_expression (viruses) of Den-2 associated with viral meningitis
5) Confidence 0.41 Published 2006 Journal Virol J Section Body Doc Link PMC1360082 Disease Relevance 0.71 Pain Relevance 0.05
The result indicated that all the 17 samples were positive for DEN-3 specific RNA.


Gene_expression (positive) of DEN
6) Confidence 0.24 Published 2006 Journal Virol J Section Body Doc Link PMC1559593 Disease Relevance 0.58 Pain Relevance 0
Patients with other non-dengue febrile illnesses (OFI) were defined by febrile illness with no detectable DEN-specific IgM, no detectable DEN RNA, and no obvious or reported bacterial etiology for their illness during the same study period.
Neg (no) Gene_expression (detectable) of DEN associated with dengue and fever
7) Confidence 0.13 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.74 Pain Relevance 0.07
These results differ from a previous study by Loach et al. who demonstrated that the DC-SIGN expression levels on Raji cells after transfection of various DC-SIGN cDNA constructs were significantly correlated to the infection rate of DEN-1 [35].
Gene_expression (expression) of DEN-1 in Raji associated with infection
8) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.26 Pain Relevance 0.07
We are the first in the field to demonstrate the relationship among functional cell surface expression, viral replication, and immune responses in DEN-infected MDDCs from subjects with rs4804803 SNP.
Gene_expression (expression) of DEN
9) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.38 Pain Relevance 0
Patients with other non-dengue febrile illnesses (OFI) were defined by febrile illness with no detectable DEN-specific IgM, no detectable DEN RNA, and no obvious or reported bacterial etiology for their illness during the same study period.
Gene_expression (illness) of DEN associated with dengue and fever
10) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.75 Pain Relevance 0.07
With both genotypes, the viral replication 24 h post DEN infection increased significantly more in the presence of neutralizing antibody than in the absence of neutralizing antibody (p?
Gene_expression (infection) of DEN associated with infection
11) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.44 Pain Relevance 0
CLEC5A-mediated DEN infection in animals that was susceptible to DEN hemorrhagic infection also revealed augmented immune response [40].
Gene_expression (infection) of DEN associated with infection
12) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.56 Pain Relevance 0
, IL-12p40, and chemokine IP-10 production in DEN-infected MDDCs with AG genotype of rs4804803
Gene_expression (production) of DEN associated with chemokine
13) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.64 Pain Relevance 0.19
IP-10, produced by non-infected bystander DCs in response to DEN infection, is a potent chemoattractant for activated T and NK cells [26], and the modulation of adaptive immune response [27].
Gene_expression (infection) of DEN in NK cells associated with infection
14) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.46 Pain Relevance 0.03
Based on these results, we hypothesized that DEN-infected MDDCs with AG genotype produced higher levels of IP-10, which might block viral entry or viral replication in MDDCs.
Gene_expression (produced) of DEN
15) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.40 Pain Relevance 0
IP-10 production by MDDCs involved in viral replication of DEN infection
Gene_expression (infection) of DEN associated with infection
16) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.46 Pain Relevance 0.03
CLEC5A-mediated DEN infection in animals that was susceptible to DEN hemorrhagic infection also revealed augmented immune response [40].
Gene_expression (infection) of DEN associated with infection
17) Confidence 0.12 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 0.55 Pain Relevance 0
Our results suggest that humans carrying the rs4804803 AG genotype have a higher DC-SIGN expression and lower DEN-2 replication in MDDCs.
Gene_expression (expression) of DEN
18) Confidence 0.10 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.40 Pain Relevance 0.04
Protective effect of HLA-DRB1*0901 against DSS development from DHF was evident when having DEN-2 infection
Gene_expression (infection) of DEN-2 associated with dengue hemorrhagic fever and infection
19) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 0.77 Pain Relevance 0
The correlation between DEN-2 infection and the severe clinical forms (Table 2) provided additional proof for higher virulence of this serotype because previous study reported that patients with DEN-2 had a larger pleural effusion index than those infected by other virus serotypes [32].


Gene_expression (infection) of DEN-2 associated with pleural effusion and infection
20) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 0.92 Pain Relevance 0

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