INT189968

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.10
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (APOA1) small molecule metabolic process (APOA1) extracellular region (APOA1)
plasma membrane (APOA1) enzyme binding (APOA1) transmembrane transport (APOA1)
Anatomy Link Frequency
plasma 3
endothelial cells 1
liver 1
intestine 1
APOA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 92.88 High High
Multiple sclerosis 6 81.64 Quite High
Neuropeptide 2 55.44 Quite High
Inflammatory response 4 16.56 Low Low
Central nervous system 71 12.08 Low Low
Bile 48 6.08 Low Low
imagery 227 5.00 Very Low Very Low Very Low
cva 22 5.00 Very Low Very Low Very Low
positron emission tomography 22 5.00 Very Low Very Low Very Low
Angina 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 681 100.00 Very High Very High Very High
Cardiovascular Disease 125 97.60 Very High Very High Very High
Glioblastoma 6 97.24 Very High Very High Very High
Cancer 58 94.88 High High
Disease 58 93.76 High High
INFLAMMATION 54 92.88 High High
Motor Neuron Diseases 1 92.80 High High
Mental Disorders 2 91.32 High High
Neuromyelitis Optica 81 87.44 High High
Obesity 95 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They hypothesized that this may be facilitated by the interaction of apolipoprotein A-I, present on the surface of the NPs, with the scavenger receptor class B, type I, the prime receptor for high density lipoprotein/apoA-I that is expressed on brain capillary endothelial cells (BCEC) [81].
apolipoprotein A-I Binding (interaction) of in endothelial cells associated with disorder of lipid metabolism
1) Confidence 0.47 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.62 Pain Relevance 0
Thirdly, association with other SNPs namely the ApoA1, +83C>T or APOA5, S19W was not observed probably due to a low MAF.
ApoA1 Binding (association) of
2) Confidence 0.38 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.18 Pain Relevance 0
The other SNPs, namely the -75G>A and the +83C>T SNPs, were significantly associated with plasma LDL-cholesterol and ApoA1 levels by multivariate analysis in our study.
ApoA1 Binding (associated) of in plasma
3) Confidence 0.38 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.40 Pain Relevance 0
They reported preferential adsorbtion of apolipoprotein E and apolipoprotein A-I in the in vitro studies, thereby suggesting the RME transport of chelators and chelator-metal complexes by the NPs across the BBB.
apolipoprotein A-I Binding (adsorbtion) of associated with disorder of lipid metabolism
4) Confidence 0.36 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.52 Pain Relevance 0.03
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of in plasma associated with disorder of lipid metabolism
5) Confidence 0.36 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.17 Pain Relevance 0
The population average ApoB/ApoA1 ratio (BARP) can be estimated from values for the age and gender-adjusted estimates of TC and HDL using the coefficients in Additional file 1, thus:
ApoA1 Binding (average) of associated with disorder of lipid metabolism
6) Confidence 0.36 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2601038 Disease Relevance 1.43 Pain Relevance 0
(Hocher et al. 2003), who have found apoA-I or apoB not to be significantly associated with cardiovascular mortality.
apoA-I Binding (associated) of
7) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0.05
ApoA-I induced cholesterol release is not linked to cholesterol synthesis
ApoA-I Binding (linked) of
8) Confidence 0.30 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.30 Pain Relevance 0
Apolipoprotein A-I (apoA-I) and apoB concentrations were determined by immunoturbodimetric assays (Tina-quant, Roche Diagnostics, Germany).
apoA-I Spec (determined) Binding (determined) of associated with disorder of lipid metabolism
9) Confidence 0.15 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.28 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of in liver associated with disorder of lipid metabolism
10) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.17 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of in intestine associated with disorder of lipid metabolism
11) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.17 Pain Relevance 0
As shown in Figure 4, TTR, ApoA-I, and HDL strictly interact through physical binding.
ApoA-I Binding (binding) of associated with disorder of lipid metabolism
12) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.05 Pain Relevance 0.23
In univariate analysis, PLTP activity was significantly positively associated with plasma triglyceride (TG), apolipoprotein (apo)B and apoE, while it was negatively associated with plasma HDL and apoA-I.
apoA-I Binding (associated) of in plasma associated with disorder of lipid metabolism
13) Confidence 0.08 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 1.00 Pain Relevance 0

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