INT189988

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pawr) nucleus (Pawr) enzyme binding (Pawr)
cytoplasm (Pawr)
Anatomy Link Frequency
platelets 1
Pawr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 99.96 Very High Very High Very High
COX2 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 43 100.00 Very High Very High Very High
Injury 1 95.56 Very High Very High Very High
Hemorrhage 7 92.68 High High
Cancer 170 90.28 High High
Coagulation Disorder 1 84.56 Quite High
Bone Cancer 12 50.00 Quite Low
Thrombosis 5 37.60 Quite Low
Metastasis 18 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Lung Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, this study also reported a small increase in the time taken for platelets to change shape in response to convulxin and PAR-4 agonists although aggregation appeared normal.
Regulation (response) of PAR-4 in platelets associated with agonist
1) Confidence 0.13 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.40 Pain Relevance 0.05
Cox-2 dependent mechanisms are based on a decreased production of PGE2 which is associated with the modulation of pro- and antiapoptotic factors such as Bcl-2 and the prostate apoptosis-response gene (PAR-4) [17,38].
Regulation (modulation) of PAR-4 associated with apoptosis
2) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 1.43 Pain Relevance 0
Cox-2 dependent mechanisms are based on a decreased production of PGE2 which is associated with the modulation of pro- and antiapoptotic factors such as Bcl-2 and the prostate apoptosis-response gene (PAR-4) [17,38].
Regulation (modulation) of apoptosis-response gene associated with apoptosis
3) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 1.43 Pain Relevance 0

General Comments

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