INT189991

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 23
Disease Relevance 4.93
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Tymp)
Anatomy Link Frequency
endothelial cell 1
Tymp (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 440 99.84 Very High Very High Very High
cytokine 1 84.68 Quite High
Kinase C 22 65.20 Quite High
antagonist 22 62.64 Quite High
rheumatoid arthritis 1 56.20 Quite High
Angina 22 43.44 Quite Low
COX2 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 352 99.98 Very High Very High Very High
Cancer 85 97.84 Very High Very High Very High
Apoptosis 43 96.76 Very High Very High Very High
Malignant Neoplastic Disease 5 88.04 High High
Atherosclerosis 22 87.40 High High
Myocardial Infarction 22 78.76 Quite High
Hypersensitivity 22 77.48 Quite High
Hypoxia 1 75.24 Quite High
Increased Venous Pressure Under Development 44 73.40 Quite High
Solid Tumor 3 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore oxidative stress induced a rapid sustained upregulation of HA-TP?
Positive_regulation (upregulation) of TP associated with stress
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.22 Pain Relevance 0
We hypothesized that this additional responsiveness to the isoprostane was due to an increased TP?
Positive_regulation (increased) of TP
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.63 Pain Relevance 0.04
Exposure of PC3 cells to H2O2 resulted in an increase of endogenous TP?
Positive_regulation (increase) of TP
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
Addition of H2O2 was found to lead to an increase in detectable surface TP?
Positive_regulation (increase) of TP
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.04
The enzyme is localized in neoplastic cells, endothelial cells, and stromal tissues [9,11-13] and contributes to tumor angiogenesis and tumor growth by (1) an increased expression of the angiogenic growth factor VEGF [14], (2) the production of eicosanoid products which can directly stimulate endothelial cell growth factor induced angiogenesis [15], and (3) the inhibition of tumor and endothelial cell apoptosis by up regulating the antiapoptotic protein bcl-2 [16,17].
Positive_regulation (stimulate) of endothelial cell growth factor in endothelial cell associated with cancer and apoptosis
5) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 1.47 Pain Relevance 0.07
from the ER to the Golgi complex as a consequence of TP activation via a reactive oxygen species-dependent mechanism has also recently been reported [11].
Positive_regulation (activation) of TP
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.18 Pain Relevance 0.03
More recently we provided empirical evidence to support this hypothesis by demonstrating that oxidative stress promoted TP?
Positive_regulation (promoted) of TP associated with stress
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.57 Pain Relevance 0.04
The almost eight-fold increase in TP?
Positive_regulation (increase) of TP
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.08 Pain Relevance 0
PC3 cells express a large intracellular pool of thromboxane receptor and both the TP?
Positive_regulation (pool) of TP
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
A model for these changes to TP?
Positive_regulation (changes) of TP
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.10 Pain Relevance 0.04
receptor, and that hydrogen peroxide alone is capable of inducing calcium mobilization [17], [18], [19], these earlier investigations used hydrogen peroxide concentrations very much higher than the current study and we observed that treatment with 10 ┬ÁM hydrogen peroxide had no observable effect on calcium mobilization in the absence of TP?
Positive_regulation (absence) of TP
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.05
from the ER into the Golgi complex, inducing maturation and stabilization of TP?.
Positive_regulation (stabilization) of TP
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2939892 Disease Relevance 0.07 Pain Relevance 0
two-fold increase in TP?
Positive_regulation (increase) of TP
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.09 Pain Relevance 0
Increased TP?
Positive_regulation (Increased) of TP
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.09 Pain Relevance 0
Therefore the proteasome degrades a significant population of TP?
Positive_regulation (population) of TP
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.13 Pain Relevance 0
Increased TP?
Positive_regulation (Increased) of TP
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0
receptor at the cell-surface suggests proteasomal involvement in ER-derived TP?
Positive_regulation (derived) of TP
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.10 Pain Relevance 0
Specifically, an increase to the cell-surface TP?
Positive_regulation (increase) of TP
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.14 Pain Relevance 0.15
However, in the presence of H2O2, this effect was markedly potentiated, suggesting that the increase in TP?
Positive_regulation (increase) of TP
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.14
The present study extends that work by demonstrating that simulating oxidative stress in isolated cells by treatment with hydrogen peroxide causes an enhanced and prolonged increase in the response of TP?
Positive_regulation (increase) of TP associated with stress
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.52 Pain Relevance 0.03

General Comments

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