INT189992

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.89 Pain Relevance 0

plasma membrane (Ptger2, Pawr) signal transduction (Ptger2) nucleus (Pawr) enzyme binding (Pawr) cytoplasm (Pawr) signal transducer activity (Ptger2)

Ptger2 (Mus musculus) Pawr (Mus musculus)

Pain Link Frequency Relevance Heat COX2 2 5.00 palliative 2 5.00 cytokine 2 5.00 ketamine 2 5.00 anesthesia 2 5.00 rheumatoid arthritis 2 5.00 cva 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 42 100.00 Cancer 170 91.64 Bone Cancer 12 50.00 Metastasis 18 5.00 Body Weight 12 5.00 Lung Cancer 12 5.00 Malignant Neoplastic Disease 10 5.00 Solid Tumor 6 5.00 Severe Combined Immunodeficiency 6 5.00 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cox-2 dependent mechanisms are based on a decreased production of PGE2 which is associated with the modulation of pro- and antiapoptotic factors such as Bcl-2 and the prostate apoptosis-response gene (PAR-4) [17,38].

PGE2 Binding (associated) of PAR-4 associated with apoptosis

1) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 1.45 Pain Relevance 0

Cox-2 dependent mechanisms are based on a decreased production of PGE2 which is associated with the modulation of pro- and antiapoptotic factors such as Bcl-2 and the prostate apoptosis-response gene (PAR-4) [17,38].

PGE2 Binding (associated) of apoptosis-response gene associated with apoptosis

2) Confidence 0.00 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1360103 Disease Relevance 1.44 Pain Relevance 0

General Comments

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