INT189998

Context Info Confidence 0.22 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.44 Pain Relevance 0.10

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)

Prf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Eae 13 78.92 Nucleus accumbens 36 63.16 Ventral tegmentum 37 62.96 Dopamine 30 5.00 Central nervous system 5 5.00 anesthesia 3 5.00 cocaine 3 5.00 drug abuse 2 5.00 addiction 2 5.00 hyperexcitability 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 1 98.06 Injury 20 95.96 Brain Injury 1 87.04 Attention Deficit Hyperactivity Disorder 13 5.00 Cognitive Disorder 6 5.00 Drug Dependence 3 5.00 Dyslexia 3 5.00 Anxiety Disorder 2 5.00 Pain 1 5.00 Cv Unclassified Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Given prior evidence that early focal cortical lesions induce abnormalities in cortical morphology and connectivity [1-4], we hypothesized that the differential behavioral effects of focal cortical lesions on P1, P3 or P5 may be associated with underlying neuroanatomical changes that are sensitive to timing of injury.

Regulation (effects) of P1 associated with congenital anomalies and injury

1) Confidence 0.22 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2204005 Disease Relevance 0.44 Pain Relevance 0

The acoustic sensory evoked response on a rat exhibited five main components: P1, N1, P2, N2, and P3.

Regulation (response) of P1

2) Confidence 0.06 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.10

General Comments

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