INT190011

Context Info Confidence 0.23 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.76 Pain Relevance 0

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1) intracellular (Apaf1) cytoplasm (Apaf1)

Apaf1 (Mus musculus)

Pain Link Frequency Relevance Heat addiction 2 5.00 cINOD 2 5.00 iatrogenic 1 5.00 agonist 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 41 99.22 Cancer 116 83.04 Hyperplasia 1 53.12 Lymphatic System Cancer 7 21.20 Genomic Instability 2 7.16 Endometriosis (extended) 1 5.52 Colorectal Cancer 26 5.00 Endometrial Cancer 14 5.00 Death 6 5.00 Syndrome 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).

Negative_regulation (targeted) of Gene_expression (mutation) of APAF-1 associated with apoptosis

1) Confidence 0.23 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0

General Comments

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