INT190014

Context Info Confidence 0.62 First Reported 2006 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 8 Total Number 10 Disease Relevance 6.03 Pain Relevance 1.20

phosphatase activity (Pten) mitochondrion (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency neuronal 1 brain 1 Pten (Mus musculus)

Pain Link Frequency Relevance Heat Potency 105 98.32 Dopamine 345 98.08 rheumatoid arthritis 52 88.16 Serotonin 9 84.12 Ventral tegmentum 24 84.00 Arthritis 5 73.80 Inflammation 142 71.76 midbrain 45 64.64 agonist 24 39.52 Eae 21 23.84

Disease Link Frequency Relevance Heat Cancer 285 100.00 Endometrial Cancer 81 98.96 Apoptosis 210 95.48 Brain Tumor 4 92.92 Metastasis 3 89.12 Rheumatoid Arthritis 54 88.16 Hepatotoxicity 78 87.80 Disease 46 85.84 Death 40 84.08 Injury 19 80.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, PTEN activity has been related to mitochondrial function in different neuronal systems, suggesting PTEN deregulation may provide a dual neuroprotective function in dopamine cells by the activation of survival pathways and maintenance of mitochondrial function.

Regulation (deregulation) of PTEN in neuronal associated with dopamine

1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.29 Pain Relevance 0.25

We examined the effects of Pten deletion on amphetamine-induced rotational asymmetry at different time points after 6OHDA lesioning.

Spec (examined) Regulation (effects) of Pten

2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.19

As PTEN is a tumor suppressor gene and deregulation of this pathway has been associated with the formation of multiple tumor types, the animals used for morphological evaluations in this study were examined for the existence of brain tumors.

Spec (examined) Regulation (deregulation) of PTEN in brain associated with cancer and brain tumor

3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.43 Pain Relevance 0.23

These results suggest a synergistic effect of dysregulation of the PTEN and K-ras signaling pathways during endometrial tumorigenesis. 3.2.

Regulation (dysregulation) of PTEN

4) Confidence 0.23 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.38 Pain Relevance 0

In MMR-deficient mouse model experiments, Pten, a gene mutated also in human MMR defective cancers (103), was shown to be an important target whose mutation increases endometrial cancer rates (160).

Regulation (target) of Pten associated with cancer and endometrial cancer

5) Confidence 0.19 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.07 Pain Relevance 0

B interactions and negative regulation of other nuclear factors such as Akt (protein kinase B) are dependent on PTEN [64].

Regulation (dependent) of PTEN

6) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 1.06 Pain Relevance 0.19

Our results clearly demonstrate the ability to improve potency with some, but not all, LNA containing ASO designs, particularly for the TRADD and PTEN targets.

Regulation (targets) of PTEN associated with potency

7) Confidence 0.11 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.38 Pain Relevance 0.20

Three active ASO sequences (6, 8 and 9, Table 1) targeting either mouse ApoB or mouse PTEN were identified in cell culture assays using methods previously described for these targets.

Regulation (targeting) of PTEN

8) Confidence 0.09 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1802611 Disease Relevance 0.49 Pain Relevance 0.13

In an inactivated state, such as that induced by the up-regulation of PTEN, Bad may become unphosphorylated, disassociate from 14-3-3 and move to displace Bax [75],[88].

Regulation (regulation) of PTEN

9) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.37 Pain Relevance 0

The mammalian target of rapamycin (mTOR), one of the targets of the PTEN/Pi3K pathway, is a conserved kinase that regulates central cellular functions in response to environmental signals, such as transcription and translation, mRNA and protein turnover, or autophagy (reviewed in [190, 191]).

Regulation (targets) of PTEN

10) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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