INT190020

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.69
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh2) ATPase activity (Msh2) nucleus (Msh2)
enzyme binding (Msh2) cell cycle (Msh2) DNA binding (Msh2)
Anatomy Link Frequency
MLH1 1
Msh2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 15 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
monoamine 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 116 96.76 Very High Very High Very High
Microsatellite Instability 1 72.40 Quite High
Disease 166 47.08 Quite Low
Targeted Disruption 32 46.56 Quite Low
Apoptosis 41 6.56 Low Low
Colorectal Cancer 26 5.00 Very Low Very Low Very Low
Endometrial Cancer 14 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 12 5.00 Very Low Very Low Very Low
Syndrome 9 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Msh3, Ogg1 and Cbp did not correlate with instability index and Msh2 expression level showed a weak negative correlation with instability index (Figure 6A, Additional file 2).
Gene_expression (expression) of Msh2
1) Confidence 0.69 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
To probe these processes further, we examined whether expression levels of specific DNA repair genes (Msh2, Msh3, Ogg1 and Cbp), previously shown to play important roles in CAG repeat instability [8,13,14,21,24-26], correlated with instability index measured in 16 tissues.
Spec (whether) Gene_expression (expression) of Msh2
2) Confidence 0.69 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
In agreement with these findings, and further validating the predictive power of our signature, protein levels of Msh2 (Figure 6B) and Cbp (data not shown) did not correlate with instability index.
Gene_expression (levels) of Msh2
3) Confidence 0.54 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
MSI mutation rates in these short repetitive sequences in MLH1- or MSH2-deficient cells are estimated to be more than 100 times higher than that seen in MMR-proficient cells and used to test directly whether MMR deficiency is involved in specific tumor types.
Gene_expression (deficient) of MSH2 in MLH1 associated with cancer
4) Confidence 0.44 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.69 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox