INT190022

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.16
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Mlh1) ATPase activity (Mlh1) nucleus (Mlh1)
cell cycle (Mlh1)
Anatomy Link Frequency
uterus 1
MLH1 1
Mlh1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 52.64 Quite High
iatrogenic 1 16.00 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 176 99.92 Very High Very High Very High
Microsatellite Instability 16 98.60 Very High Very High Very High
Endometroid Carcinoma 12 96.56 Very High Very High Very High
Endometrial Cancer 81 89.92 High High
Hematologic Neoplasms 2 75.40 Quite High
Colon Cancer 6 73.92 Quite High
Myeloid Leukemia 1 73.68 Quite High
Watson Syndrome 2 71.80 Quite High
Aneuploidy 3 70.24 Quite High
Genomic Instability 7 60.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As there is substantial evidence that inherited versus sporadically acquired mutations significantly influence the types of tumors that develop [reviewed in (140)], and all the current described MMR mouse models use germline mutations, future experiments involving inducible Mlh1 or Msh2 mutations using Cre-Lox technology in ovary, kidney or uterus will be important to test whether these models develop cancers in those tissues.


Positive_regulation (inducible) of Mlh1 in uterus associated with cancer
1) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.86 Pain Relevance 0.03
Inactivation of the mismatch repair gene MLH1 by methylation of the promoter seems to be the most frequent cause of MI in sporadic endometrioid carcinomas, followed by a loss of the expression of other two mismatch repair genes, the MSH2 and MSH6 genes.
Positive_regulation (Inactivation) of MLH1 in MLH1 associated with endometroid carcinoma and microsatellite instability
2) Confidence 0.28 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.30 Pain Relevance 0

General Comments

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