INT190026

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 68.88 Quite High
headache 1 16.32 Low Low
long-term potentiation 5 14.00 Low Low
gABA 7 9.68 Low Low
dopamine receptor 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 99.98 Very High Very High Very High
Watson Syndrome 32 99.60 Very High Very High Very High
Cancer 233 99.12 Very High Very High Very High
Cognitive Disorder 18 97.04 Very High Very High Very High
Congenital Anomalies 1 95.76 Very High Very High Very High
Hematologic Neoplasms 4 91.64 High High
Myeloid Leukemia 2 89.92 High High
Apoptosis 82 69.92 Quite High
Targeted Disruption 10 50.00 Quite Low
Leukemia 4 48.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mice, presumably by inactivating Nf1 gene expression as a myeloid lineage tumor suppressor gene.
Positive_regulation (inactivating) of Gene_expression (expression) of Nf1 associated with cancer
1) Confidence 0.53 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.82 Pain Relevance 0.03
Heat-shock induced neurofibromin was expressed in adult NF1-/- fruit flies, rescuing the learning deficits, indicating that developmental factors are not causing the cognitive deficits [10].
Positive_regulation (induced) of Gene_expression (expressed) of neurofibromin associated with cognitive disorder, shock and watson syndrome
2) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.80 Pain Relevance 0
These results suggest that MMR deficiency can accelerate myeloid leukemogenesis in Nf1+/?
Positive_regulation (accelerate) of Gene_expression (/) of Nf1
3) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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