INT190028

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.94
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Anatomy Link Frequency
spike 2
hippocampus 2
neurons 1
respiratory 1
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 115 99.32 Very High Very High Very High
depression 72 98.40 Very High Very High Very High
antagonist 48 98.12 Very High Very High Very High
corticosteroid 603 93.56 High High
amygdala 38 93.36 High High
Calcium channel 48 92.40 High High
imagery 26 91.00 High High
long-term potentiation 71 86.16 High High
nMDA receptor 60 80.68 Quite High
Neuronal excitability 24 80.64 Quite High
Disease Link Frequency Relevance Heat
Depression 72 98.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 98.24 Very High Very High Very High
Cancer 122 97.96 Very High Very High Very High
Endometrial Cancer 14 94.92 High High
Stress 282 93.40 High High
Dementia 6 82.36 Quite High
Cognitive Disorder 68 80.76 Quite High
Neurodegenerative Disease 23 78.60 Quite High
Colorectal Cancer 26 68.64 Quite High
Disease 12 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their MUAP counting algorithm was able to estimate MR reliably up to 100 pps from these signals, which seems a better performance than that of the algorithm we applied.
Positive_regulation (estimate) of MR
1) Confidence 0.22 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1557523 Disease Relevance 0 Pain Relevance 0
In MMR-deficient mouse model experiments, Pten, a gene mutated also in human MMR defective cancers (103), was shown to be an important target whose mutation increases endometrial cancer rates (160).
Positive_regulation (experiments) of MMR-deficient associated with cancer and endometrial cancer
2) Confidence 0.22 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.00 Pain Relevance 0
On the other hand, increased GR and/or MR activity in the hippocampus normalizes the hyperactivity of the HPA axis, because the hippocampus plays a major role in mediating negative feedback of glucocorticoids [97].
Positive_regulation (increased) of MR in hippocampus associated with hippocampus and attention deficit hyperactivity disorder
3) Confidence 0.17 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.41 Pain Relevance 0.40
Importantly, 30 nM of corticosterone, which activates nGR (as well as nMR), decreased spike numbers and increased AHP amplitude, leading the authors to conclude that the bifurcating actions of low and high doses of corticosterone reflect the activation of nMR and nGR, respectively [96].
Positive_regulation (activation) of nMR in spike
4) Confidence 0.11 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.09 Pain Relevance 0.22
MR data acquisition is directly triggered by the ECG signal, or using the retrospective approach [10,11], i.e., data is continuously collected during the experiment and subsequently reconstructed by using the stored respiratory and ECG information to assign the data to respiratory and/or cardiac phases.
Positive_regulation (triggered) of MR in respiratory
5) Confidence 0.10 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2918602 Disease Relevance 0.29 Pain Relevance 0.18
Importantly, 30 nM of corticosterone, which activates nGR (as well as nMR), decreased spike numbers and increased AHP amplitude, leading the authors to conclude that the bifurcating actions of low and high doses of corticosterone reflect the activation of nMR and nGR, respectively [96].
Positive_regulation (activates) of nMR in spike
6) Confidence 0.09 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.08 Pain Relevance 0.25
The hippocampus also serves as an important homeostatic regulator of the HPA axis upon which it exerts a strong negative drive [36,37] through the mediation of nMR and nGR [38].
Positive_regulation (mediation) of nMR in hippocampus associated with hippocampus
7) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.24 Pain Relevance 0.55
Results from Takahashi et al. also dismissed a mediatory role for nGR or nMR in the mediation of corticosterone effects; however, they reported that the steroid prolongs the elevation of NMDAR-mediated Ca2+ influx in dissociated hippocampal neurons independently of VDCC and mobilization of intracellular Ca2+ stores [111].
Positive_regulation (role) of nMR in neurons associated with calcium channel
8) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.18
Glucocorticoids and mineralocorticoids fulfill their characteristic biological functions through the mediation of glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), respectively.
Positive_regulation (mediation) of MR
9) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.50 Pain Relevance 0.28
It is thus estimated that the MR is some 80% occupied under basal conditions, and that the GR only becomes activated when corticosterone levels rise during the daily circadian peak of corticosterone secretion or after stress.
Positive_regulation (occupied) of MR associated with stress
10) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.33 Pain Relevance 0.19

General Comments

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