INT190032

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.74
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdx2) nucleus (Cdx2) DNA binding (Cdx2)
protein complex (Cdx2)
Cdx2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 84.64 Quite High
agonist 1 76.92 Quite High
methotrexate 34 76.00 Quite High
Inflammation 3 75.32 Quite High
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 26 98.92 Very High Very High Very High
Cancer 118 85.12 High High
Colon Cancer 1 80.08 Quite High
Intestinal Cancer 1 78.36 Quite High
INFLAMMATION 3 75.32 Quite High
Stomach Cancer 5 69.48 Quite High
Mucositis 29 50.00 Quite Low
Ureteral Neoplasms 1 49.04 Quite Low
Renal Cancer 4 39.84 Quite Low
Nicotine Addiction 3 17.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the decrease in BMP4 might result in a decrease in Cdx2 and HNF-1?
Negative_regulation (decrease) of Cdx2
1) Confidence 0.38 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0.04
As CDX2 down-regulation is frequently observed in colorectal cancer and mutations and lower expression are strongly associated with MSI-H CRCs (133), it would be interesting to test directly, perhaps using mouse models, whether dietary modulation of Cdx2 function might be an important mechanism that underlies the shifts along the different epithelia along the lower GI tract for MMR defective tumors.
Negative_regulation (regulation) of CDX2 associated with colorectal cancer and cancer
2) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.74 Pain Relevance 0.24
Furthermore, the decrease in BMP4 might also indirectly cause the observed decrease in SI expression, because inhibition of BMP4 stimulates Wnt signaling, and Wnt signaling itself induces SOX9, a negative regulator of Cdx2, which is a SI transcriptional activator [3, 10, 39].
Negative_regulation (regulator) of Cdx2
3) Confidence 0.28 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0.03

General Comments

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