INT190033

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 232 99.68 Very High Very High Very High
Malignant Neoplastic Disease 10 94.72 High High
Colorectal Cancer 52 92.16 High High
Apoptosis 82 80.88 Quite High
Death 12 62.00 Quite High
Endometrial Cancer 28 59.04 Quite High
Uterine Cancer 2 42.80 Quite Low
Hematologic Neoplasms 4 25.44 Quite Low
Lymphatic System Cancer 14 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that human and mouse null mutations for critical MMR genes allow essentially normal development demonstrate clearly that the loss of MMR alone is insufficient to initiation a carcinogenic transforming event, but that additional genetic changes are also required for the transition to frank malignancy.
Positive_regulation (insufficient) of Negative_regulation (loss) of MMR associated with malignant neoplastic disease
1) Confidence 0.22 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.67 Pain Relevance 0
The spectrum of cancer susceptibility attributable to MMR deficiency
Positive_regulation (attributable) of Negative_regulation (deficiency) of MMR associated with cancer
2) Confidence 0.22 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.79 Pain Relevance 0

General Comments

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