INT190034

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ighmbp2) nucleus (Ighmbp2) DNA binding (Ighmbp2)
transcription factor binding (Ighmbp2) cytoplasm (Ighmbp2)
Ighmbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 71.44 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Muscular Atrophy 32 100.00 Very High Very High Very High
Cancer 119 96.60 Very High Very High Very High
Carcinoma 1 65.60 Quite High
Targeted Disruption 9 64.44 Quite High
Repression 1 48.20 Quite Low
Colorectal Cancer 26 43.96 Quite Low
Apoptosis 41 5.00 Very Low Very Low Very Low
Endometrial Cancer 14 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SMA murine model expresses the genomic human SMN2 gene and the human SMN?
Transcription (model) of SMA associated with spinal muscular atrophy
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565107 Disease Relevance 0.39 Pain Relevance 0.06
Experiments in cell lines using this approach and selective stabilization of NMD targeted mRNA transcripts with chemical or genetic approaches has suggested UVRAG, p300 and GRK as potential important targets in MSI-H CRCs (89,90).
Transcription (transcripts) of NMD
2) Confidence 0.06 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.57 Pain Relevance 0
Specifically, we showed that Haplotype A-derived mRNA encodes full-length, canonical ERAP2, while Haplotype B-derived mRNA undergoes differential splicing and NMD, resulting in undetectable levels of ERAP2.
Transcription (splicing) of NMD
3) Confidence 0.04 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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