INT190035

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Msh6)
Anatomy Link Frequency
germline 1
Msh6 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 81 99.44 Very High Very High Very High
Microsatellite Instability 16 95.80 Very High Very High Very High
Cancer 176 95.24 Very High Very High Very High
Malignant Neoplastic Disease 11 87.76 High High
Colon Cancer 6 86.60 High High
Aneuploidy 3 75.80 Quite High
Genomic Instability 7 73.52 Quite High
Mucositis 1 73.08 Quite High
Apoptosis 45 73.04 Quite High
Death 6 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSH2–MSH6 can specifically recognize distinct types of damaged DNA (such as those caused by oxidative or alkylating agents).
MSH6 Binding (recognize) of
1) Confidence 0.28 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.51 Pain Relevance 0
HNPCC patients with endometrial cancers have an inherited germline mutation in MLH-1, MSH-2, MSH-6, or PMS-2, but endometrial cancer only develops after the instauration of a deletion or mutation in the contralateral MLH-1, MSH-2, MSH-6, or PMS-2 allele.
MSH-6 Binding (mutation) of in germline associated with endometrial cancer
2) Confidence 0.22 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.21 Pain Relevance 0

General Comments

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