INT190037

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Anatomy Link Frequency
germline 2
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 31.00 Quite Low
agonist 2 23.28 Low Low
Inflammation 2 21.68 Low Low
addiction 4 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 82 99.22 Very High Very High Very High
Cancer 232 99.10 Very High Very High Very High
Renal Cancer 8 93.04 High High
Ureteral Neoplasms 2 73.28 Quite High
Chronic Myeloid Leukemia 2 69.92 Quite High
Lymphatic System Cancer 14 66.64 Quite High
Neurofibroma 2 65.20 Quite High
Watson Syndrome 4 62.64 Quite High
Glioblastoma 2 59.68 Quite High
Hyperplasia 2 51.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Negative_regulation (targeted) of Gene_expression (mutation) of MMR-deficient associated with apoptosis
1) Confidence 0.21 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
Target genes in tumors from germline recessive versus sporadically acquired MMR deficiency
Negative_regulation (acquired) of Gene_expression (deficiency) of MMR in germline associated with cancer
2) Confidence 0.18 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.10 Pain Relevance 0

General Comments

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