INT190038

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Mlh1) ATPase activity (Mlh1) nucleus (Mlh1)
cell cycle (Mlh1)
Anatomy Link Frequency
germline 1
MLH1 1
Mlh1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 26 99.76 Very High Very High Very High
Endometrial Cancer 81 99.44 Very High Very High Very High
Cancer 176 97.04 Very High Very High Very High
Microsatellite Instability 16 95.80 Very High Very High Very High
Colon Cancer 6 86.60 High High
Apoptosis 45 78.56 Quite High
Aneuploidy 3 75.80 Quite High
Genomic Instability 7 73.52 Quite High
Carcinoma 10 67.88 Quite High
Endometroid Carcinoma 12 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in the MMR genes MLH1 and MSH2 were first identified because of their association with colorectal cancer in HNPCC families (4–7).
MLH1 Binding (association) of in MLH1 associated with colorectal cancer
1) Confidence 0.28 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.90 Pain Relevance 0
HNPCC patients with endometrial cancers have an inherited germline mutation in MLH-1, MSH-2, MSH-6, or PMS-2, but endometrial cancer only develops after the instauration of a deletion or mutation in the contralateral MLH-1, MSH-2, MSH-6, or PMS-2 allele.
MLH-1 Binding (mutation) of in germline associated with endometrial cancer
2) Confidence 0.21 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.21 Pain Relevance 0

General Comments

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