INT190039

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 6.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Mlh1) ATPase activity (Mlh1) nucleus (Mlh1)
cell cycle (Mlh1)
Anatomy Link Frequency
MLH1 3
lung 2
small intestine 1
Mlh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Bioavailability 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 63 99.82 Very High Very High Very High
Cancer 484 99.22 Very High Very High Very High
Lung Cancer 40 98.50 Very High Very High Very High
Colon Cancer 21 96.66 Very High Very High Very High
Genomic Instability 30 78.72 Quite High
Toxicity 44 63.28 Quite High
Chromosomal Instability 5 61.00 Quite High
Targeted Disruption 10 59.52 Quite High
Death 22 51.52 Quite High
Skin Cancer 10 42.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MSI, including MLH1 hypermethylation, has also been found in a number of human tumors of the small intestine (Ruemmele et al., 2009).
Gene_expression (found) of MLH1 in small intestine associated with cancer and microsatellite instability
1) Confidence 0.68 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.99 Pain Relevance 0
Relative to lung tumors from nonexposed individuals, tumors from chromate workers exhibit reduced expression of MLH1 as well as signs of MLH1 hypermethylation (Takahashi et al., 2005).
Gene_expression (expression) of MLH1 in lung associated with lung cancer and cancer
2) Confidence 0.68 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.10 Pain Relevance 0
Relative to lung tumors from nonexposed individuals, tumors from chromate workers exhibit reduced expression of MLH1 as well as signs of MLH1 hypermethylation (Takahashi et al., 2005).
Gene_expression (expression) of MLH1 in lung associated with lung cancer and cancer
3) Confidence 0.59 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.10 Pain Relevance 0
Immunoprecipitation of methylated H3K9 following Cr(VI) exposure was shown to coprecipitate the MLH1 promoter; moreover, the treatment of cells with Cr(VI) produced time- and dose-dependent decreases in messenger RNA (mRNA) levels of MLH1 (Sun et al., 2009).
Gene_expression (produced) of MLH1 in MLH1
4) Confidence 0.53 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.82 Pain Relevance 0
MSI mutation rates in these short repetitive sequences in MLH1- or MSH2-deficient cells are estimated to be more than 100 times higher than that seen in MMR-proficient cells and used to test directly whether MMR deficiency is involved in specific tumor types.
Gene_expression (deficient) of MLH1 in MLH1 associated with cancer
5) Confidence 0.46 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.69 Pain Relevance 0
Studies of methylation in colon cancer revealed increased frequencies of promoter methylation in the mismatch repair gene MLH1 in MSI-positive tumours suggesting that hypermethylation leads to MSI through silencing of MLH1.
Gene_expression (silencing) of MLH1 in MLH1 associated with cancer, colon cancer and microsatellite instability
6) Confidence 0.19 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717819 Disease Relevance 1.45 Pain Relevance 0

General Comments

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