INT190042

Context Info Confidence 0.05 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 7 Total Number 7 Disease Relevance 5.74 Pain Relevance 0.33

molecular_function (Bcl2a1b) cellular_component (Bcl2a1b) biological_process (Bcl2a1b)

Anatomy Link Frequency DCs 1 Bcl2a1b (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 84 83.64 Bile 12 79.52 Inflammation 70 66.20 Inflammatory response 25 60.96 anesthesia 9 58.40 ketamine 3 57.12 ischemia 22 50.00 cva 35 38.96 chemokine 13 19.20 agonist 8 7.56

Disease Link Frequency Relevance Heat Apoptosis 125 100.00 Targeted Disruption 6 99.68 Hyperplasia 1 99.56 Sepsis 68 99.28 Cancer 272 99.04 Klatskin's Tumor 28 90.08 Aging 104 88.24 Biliary Cancer 20 87.44 Injury 64 81.56 Disease 35 81.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To study the role of DC immune in LPS-induced sepsis, a transgenic mouse model with DCs overexpressing a human form of anti-apoptotic protein Bcl-2 (DC-hBcl-2 mice) has been used [28].

Gene_expression (overexpressing) of anti-apoptotic protein Bcl-2 in DCs associated with targeted disruption, apoptosis and sepsis

1) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 1.15 Pain Relevance 0.06

While the expression of the anti-apoptotic molecule Mcl-1 is decreased, that of the pro-apoptotic molecule Bax is increased.

Gene_expression (expression) of anti-apoptotic molecule Mcl-1 associated with apoptosis

2) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.10 Pain Relevance 0.10

Therefore, prognostic significance of cell cycle regulatory protein such as p53 and cyclin D1 and anti-apoptosis protein, survivin, has been investigated in malignancies [10-13].

Spec (investigated) Gene_expression (significance) of anti-apoptosis protein associated with apoptosis

3) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 2.11 Pain Relevance 0.04

Synthetic hBCL2-BH4 and hBCL2A1-BH4 peptides were both effective in reducing I/R, whereas a peptide from the BH3 domain of Bak, a pro-apoptotic BCL2 family member, was not (Figure 3).

Gene_expression (peptides) of hBCL2A1-BH4 associated with apoptosis

4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.61 Pain Relevance 0

S4A–C), and inhibited the expression of the anti-metastatic protein p53 (P<0.01, Fig.

Gene_expression (expression) of anti-metastatic protein p53

5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.06 Pain Relevance 0.04

The proliferative phase is marked by high mitotic index, and Ki-67 indicative of rapid cellular proliferation, as well as elevated levels of BCL2, an anti-apoptotic factor, presumably involved in stabilizing the cells during this period and allowing for normal physiologic growth in preparation for implantation and pregnancy (153).

Gene_expression (levels) of anti-apoptotic factor associated with apoptosis and hyperplasia

6) Confidence 0.01 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.66 Pain Relevance 0

(RmCD8-2), anti-B220 (TIB146), anti-CCR9 (7E7), and anti-gp38 (8.1.1) antibodies were produced in our laboratory.

Gene_expression (produced) of anti-B220

7) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0.06 Pain Relevance 0.09

General Comments

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