INT190043

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Anatomy Link Frequency
perivascular macrophages 1
nucleus 1
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 66.40 Quite High
amygdala 12 53.20 Quite High
corticosteroid 196 50.00 Quite Low
Hippocampus 43 47.32 Quite Low
cytokine 17 41.96 Quite Low
Inflammation 5 41.60 Quite Low
antagonist 16 11.68 Low Low
long-term potentiation 22 5.00 Very Low Very Low Very Low
depression 22 5.00 Very Low Very Low Very Low
nMDA receptor 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 47 99.72 Very High Very High Very High
Shock 10 94.32 High High
Cancer 119 89.28 High High
Stress 88 67.60 Quite High
Repression 3 66.32 Quite High
Lymphatic System Cancer 7 61.64 Quite High
Cognitive Disorder 26 50.00 Quite Low
Genomic Instability 2 47.60 Quite Low
Targeted Disruption 11 43.12 Quite Low
INFLAMMATION 12 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is notable that BAX, which helps mediate Caspase-3 inducible apoptosis, is a common target of MMR mutations.
Localization (target) of MMR associated with apoptosis
1) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.95 Pain Relevance 0
Whereas the unliganded nMR is primarily localized in the nucleus, the unoccupied nGR resides in the cytoplasm and only translocates to the nucleus upon ligand activation.
Localization (localized) of nMR in nucleus
2) Confidence 0.13 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.15 Pain Relevance 0.03
Like other nuclear receptors, nMR and nGR are organized according to canonical modules, including a ligand binding domain (LBD), a DNA binding domain (DBD), and two activation functions (AF-1 and AF-2) at their N- and C-terminals, respectively.
Localization (organized) of nMR
3) Confidence 0.12 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.21 Pain Relevance 0
Vessels were double labeled for Iba-1 (green) and mannose receptor (red), a marker for perivascular macrophages (Figure 5G–I).
Localization (labeled) of mannose receptor in perivascular macrophages
4) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0 Pain Relevance 0.03

General Comments

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