INT190046

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Msh3, Pms2) nuclear chromosome (Msh3) ATPase activity (Pms2)
nucleus (Msh3) enzyme binding (Msh3)
Anatomy Link Frequency
MLH1 1
Msh3 (Mus musculus)
Pms2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 3 82.16 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 116 97.96 Very High Very High Very High
Targeted Disruption 7 77.44 Quite High
Aging 13 75.76 Quite High
Frailty 4 50.00 Quite Low
Microsatellite Instability 1 19.36 Low Low
Colorectal Cancer 26 17.20 Low Low
Genomic Instability 2 5.72 Low Low
Apoptosis 41 5.00 Very Low Very Low Very Low
Endometrial Cancer 14 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MLH1–PMS2 is the primary MutL complex that interacts with both MSH2/6 and MSH3 complexes in mechanisms thought to be relevant to cancer prevention.
MSH3 Binding (interacts) of PMS2 in MLH1 associated with cancer
1) Confidence 0.25 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.22 Pain Relevance 0
Study of this model revealed that the mutability of the repeat is age-dependent and activity of the mismatch repair protein Msh3 (usually found associated in the Msh2/Msh3 MutS?
Msh3 Binding (associated) of mismatch
2) Confidence 0.24 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1940261 Disease Relevance 0.27 Pain Relevance 0.04

General Comments

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