INT190052

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ebp) cell differentiation (Cdx2) endoplasmic reticulum (Ebp)
nucleus (Cdx2) DNA binding (Cdx2) protein complex (Cdx2)
Cdx2 (Mus musculus)
Ebp (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 84.64 Quite High
agonist 1 76.92 Quite High
Inflammation 1 75.32 Quite High
addiction 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 26 100.00 Very High Very High Very High
Cancer 116 89.60 High High
Colon Cancer 1 80.08 Quite High
Intestinal Cancer 1 78.36 Quite High
INFLAMMATION 1 75.32 Quite High
Stomach Cancer 5 69.48 Quite High
Ureteral Neoplasms 1 58.00 Quite High
Renal Cancer 4 48.80 Quite Low
Nicotine Addiction 3 17.52 Low Low
Apoptosis 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As CDX2 down-regulation is frequently observed in colorectal cancer and mutations and lower expression are strongly associated with MSI-H CRCs (133), it would be interesting to test directly, perhaps using mouse models, whether dietary modulation of Cdx2 function might be an important mechanism that underlies the shifts along the different epithelia along the lower GI tract for MMR defective tumors.
CDX2 Binding (associated) of MSI associated with colorectal cancer and cancer
1) Confidence 0.08 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.82 Pain Relevance 0.24

General Comments

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