INT190053

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CASP5) intracellular (CASP5)
CASP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 11.20 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 48 99.96 Very High Very High Very High
Endometrial Cancer 167 99.44 Very High Very High Very High
Apoptosis 65 98.76 Very High Very High Very High
Cancer 202 90.24 High High
Colon Cancer 9 65.52 Quite High
Carcinoma 62 65.04 Quite High
Hyperplasia 20 63.44 Quite High
Lymphatic System Cancer 7 20.28 Low Low
Endometriosis (extended) 3 6.72 Low Low
Genomic Instability 2 6.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Gene_expression (mutation) of CASP-5 associated with apoptosis
1) Confidence 0.45 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
On the other hand, the expression of caspase-5 was below the detection limit in both of these cells even though the assay system was capable to detect this enzyme in other cell types (data not shown).


Gene_expression (expression) of caspase-5
2) Confidence 0.16 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].
Gene_expression (promote) of caspase-5 associated with microsatellite instability and endometrial cancer
3) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.70 Pain Relevance 0

General Comments

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