INT190081

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 18.18
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
macrophages 5
liver 2
intestinal cells 1
glial cells 1
nervous tissues 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 316 99.84 Very High Very High Very High
Inflammation 281 97.16 Very High Very High Very High
Neuropathic pain 20 94.12 High High
Peripheral nerve injury 9 89.92 High High
Bioavailability 3 89.44 High High
Spinal cord 14 85.64 High High
adenocard 7 82.28 Quite High
trigeminal ganglion 16 81.96 Quite High
Hippocampus 20 80.72 Quite High
Multiple sclerosis 63 71.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 191 99.88 Very High Very High Very High
Bacterial Respiratory Disease 3 99.72 Very High Very High Very High
Mrsa Infection 1 99.38 Very High Very High Very High
Disorder Of Lipid Metabolism 3833 99.16 Very High Very High Very High
Atherosclerotic Plaque 33 98.60 Very High Very High Very High
Colorectal Cancer 36 98.36 Very High Very High Very High
Atherosclerosis 716 97.76 Very High Very High Very High
Rickets 16 97.64 Very High Very High Very High
INFLAMMATION 291 97.16 Very High Very High Very High
Metabolic Syndrome 71 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution of ZAS3 proteins in the rat nervous tissues was first determined by immunohistochemical procedures using ZAS3-specific antisera, AbN and AbC.
Gene_expression (antisera) of AbC in nervous tissues
1) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.45 Pain Relevance 0.39
Interestingly, indomethacin down-regulates the expression of some of the ABC transporters, which are up regulated in CRC [38,41].
Gene_expression (expression) of ABC associated with colorectal cancer
2) Confidence 0.65 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.74 Pain Relevance 0.08
For WGA and GFP staining, the ABC peroxidase kit (Vector Laboratories, Burlingame, CA) was used according to the manufacturer's instructions.
Gene_expression (used) of ABC
3) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.07 Pain Relevance 0
agonists have been shown to upregulate LXR and ABCA1 expression and promote macrophage cholesterol efflux (Schmitz et al 2002; Chawla et al 2001).
Gene_expression (expression) of ABCA1 in macrophage associated with agonist
4) Confidence 0.47 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.93 Pain Relevance 0.10
and by enhancing expression of Apo AI and AII, LL, and ABCA1, which collectively enhance RCT (Tilly-Kiesi et al 1992).
Gene_expression (expression) of ABCA1
5) Confidence 0.47 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.15 Pain Relevance 0.03
Finally, crossing transgenic mice overexpressing ABCA1 with athero-susceptible transgenic mice, such as LDL receptor (LDLr) or Apolipoprotein E knockout (KO) models, reduced atheromatous progression (Joyce et al 2003).
Gene_expression (overexpressing) of ABCA1 associated with targeted disruption and disorder of lipid metabolism
6) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.57 Pain Relevance 0
agonists enhance gene expression of SR BI, Apo AI, Apo AII, LPL, and ABCA1 (Toth 2005).
Gene_expression (expression) of ABCA1 associated with agonist
7) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.63 Pain Relevance 0.26
When activated by oxysterols from FC this heterodimer stimulates ABCA1 and ABCG1 gene expression, thereby enhancing cholesterol efflux (Vaughan and Oram 2005; Venkateswaran et al 2000).
Gene_expression (expression) of ABCA1
8) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.11 Pain Relevance 0.07
HDL receives PL and FC from peripheral cells by associating with the surface protein ABCA1 (Oram and Lawn 2001), which is expressed by the liver and intestinal mucosa.
Gene_expression (expressed) of ABCA1 in liver associated with disorder of lipid metabolism
9) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.34 Pain Relevance 0
Conversely, overexpression of ABCA1 in transgenic mice is associated with increased TC, HDL-C levels, and Apo AI with enhanced cholesterol efflux and reduced levels of atherogenesis (Brewer et al 2004).
Gene_expression (overexpression) of ABCA1 associated with targeted disruption, atherosclerosis and disorder of lipid metabolism
10) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.56 Pain Relevance 0
Non-selective LXR agonists increase ABCA1 synthesis with a gradual increase in HDL-C serum levels (Lund et al 2006).
Gene_expression (synthesis) of ABCA1 associated with agonist and disorder of lipid metabolism
11) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.70 Pain Relevance 0.29
ABC transporters, particularly the ABCA1 transporter expressed in astrocytes, may also be of importance for shuttling cholesterol from glial cells to neurons.
Gene_expression (expressed) of ABCA1 in glial cells
12) Confidence 0.36 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.14 Pain Relevance 0.03
leading to increased expression of ABCA1 and CD36 in macrophages [28, 29].
Gene_expression (expression) of ABCA1 in macrophages
13) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.51 Pain Relevance 0.16
Cafestol can induce intestinal CYP27A1 and ABCA1 expression and promotes cholesterol efflux to the liver via SXR activation, which is consistent with SXR effects in intestinal cells [Li et al., 2007].
Gene_expression (expression) of ABCA1 in intestinal cells
14) Confidence 0.34 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0.07
is an oxysterol receptor that promotes cholesterol excretion and efflux by modulating expression of ATP-binding cassette transporter 1 (ABCA1) [47, 48].
Gene_expression (expression) of ATP-binding cassette transporter 1
15) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.38 Pain Relevance 0.05
is an oxysterol receptor that promotes cholesterol excretion and efflux by modulating expression of ATP-binding cassette transporter 1 (ABCA1) [47, 48].
Gene_expression (expression) of ABCA1
16) Confidence 0.34 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.38 Pain Relevance 0.05
Moreover, the authors showed that SXR can also induce ABCA1 and ABCG1 expression and promote cholesterol efflux in the same cells.
Gene_expression (expression) of ABCA1
17) Confidence 0.30 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.21 Pain Relevance 0.06
agonists induce ABCA1 and SR-BI expression in macrophages.
Gene_expression (expression) of ABCA1 in macrophages associated with agonist
18) Confidence 0.20 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.93 Pain Relevance 0.22
Cordaptive, by reducing prostaglandin D2 production, thus, may potentially cause an undesirable side effect of decreasing the ability of prostaglandin D2 to stimulate expression of ABCA-1 on the surface of macrophages.


Gene_expression (expression) of ABCA-1 in macrophages
19) Confidence 0.18 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.59 Pain Relevance 0.04
agonist that promotes expression of ABCA-1 and increases transfer of cholesterol from macrophages to HDL.
Gene_expression (expression) of ABCA-1 in macrophages associated with agonist and disorder of lipid metabolism
20) Confidence 0.18 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.75 Pain Relevance 0.05

General Comments

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