INT190089

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.21
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abca1) Golgi apparatus (Abca1) ATPase activity (Abca1)
plasma membrane (Abca1) intracellular (Abca1)
Anatomy Link Frequency
liver 1
Abca1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 98.82 Very High Very High Very High
Glutamate 2 98.16 Very High Very High Very High
agonist 62 97.84 Very High Very High Very High
adenocard 13 87.04 High High
Inflammation 53 84.32 Quite High
ischemia 3 63.68 Quite High
cytokine 78 58.80 Quite High
Spinal cord 13 56.72 Quite High
Arthritis 28 50.00 Quite Low
Kinase C 1 18.92 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 600 99.92 Very High Very High Very High
INFLAMMATION 55 84.32 Quite High
Myocardial Infarction 46 82.64 Quite High
Heart Disease 1 81.60 Quite High
Apoptosis 20 80.12 Quite High
Death 23 79.60 Quite High
Atherosclerosis 112 73.84 Quite High
Cancer 24 70.40 Quite High
Cv Unclassified Under Development 2 63.68 Quite High
Increased Venous Pressure Under Development 42 57.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AbC also reacted with two species in DRG, but with slightly retarded gel mobilities (Figure 6A, lane 4).
AbC Binding (reacted) of
1) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0 Pain Relevance 0.03
Furthermore, resveratrol activates the cholesterol efflux genes ATP-binding cassette transporter 1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1), as well as transcription factors that influence the nuclear liver receptor-?
ABCA1 Binding (binding) of in liver
2) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.45 Pain Relevance 0.03
These helical regions in the apolipoprotein of the HDL, apo A-1, similarly allows HDL to dock with the cell surface receptors ABCA-1 and SR-BI.
ABCA-1 Binding (dock) of associated with disorder of lipid metabolism
3) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0.25
These receptors include ATP-binding cassette transporter A-1 (ABCA-1), ATP-binding cassette transporter G-1 (ABCG-1), and scavenger receptor class-B type-1 (SR-B1.
ABCA-1 Binding (binding) of
4) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.70 Pain Relevance 0
On this basis, ABC1 was proposed to facilitate transport of mature IL-1?
ABC1 Binding (facilitate) of
5) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.08 Pain Relevance 0.03
Gamma glutamyl hydrolase (GGH), the enzyme responsible for glutamate removal from MTX, transforms MTX into a form that can be effluxed from the cell by the ATP-binding cassette (ABC) family of transporters.

5.

cassette Binding (binding) of associated with glutamate and methotrexate
6) Confidence 0.00 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.22 Pain Relevance 0.48

General Comments

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