INT1901

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 32.26
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Anatomy Link Frequency
granulocytes 2
liver 1
neutrophils 1
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 656 99.76 Very High Very High Very High
Arthritis 26 99.76 Very High Very High Very High
Inflammation 353 99.50 Very High Very High Very High
Pain 13 98.76 Very High Very High Very High
cva 8 98.72 Very High Very High Very High
Inflammatory response 7 97.78 Very High Very High Very High
headache 1 96.00 Very High Very High Very High
Fibrositis 2 83.64 Quite High
Angina 3 83.16 Quite High
abdominal pain 20 82.56 Quite High
Disease Link Frequency Relevance Heat
Fever 341 100.00 Very High Very High Very High
Celiac Disease 15 100.00 Very High Very High Very High
Lung Cancer 2 100.00 Very High Very High Very High
Atherosclerosis 60 99.98 Very High Very High Very High
Vasculitis 33 99.80 Very High Very High Very High
Cirrhosis 11 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.80 Very High Very High Very High
Inflammatory Bowel Disease 954 99.76 Very High Very High Very High
Disease 833 99.76 Very High Very High Very High
Arthritis 14 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NALP3 and pyrin, respectively) are known to interact together in the inflammasome molecular platform [16]–[18], we also perform gene-gene interaction analysis between common variants in the MEFV and NLRP3 region to assess whether such interactions could have masked the MEFV contribution to CD pathogenesis.
pyrin Binding (interact) of associated with crohn's disease
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.20 Pain Relevance 0.47
To assess this latter possibility, since we knew that the MEFV and the NLRP3 gene product interacted with each other, we genotyped the six SNPs in the NLRP3 region that had been previously associated with CD [3] in both the Belgian and Canadian UC sample sets and performed gene-gene interaction analysis using these six NLRP3 SNPs and the 16 SNPs genotyped in the MEFV region (i.e. 12 tagging SNPs and 4 coding SNPs in MEFV exon 2 region).
MEFV Binding (interacted) of associated with inflammatory bowel disease and crohn's disease
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.26 Pain Relevance 0.05
A unique case of TMJ synovitis with effusion associated with FMF is described.
FMF Binding (associated) of associated with synovitis
3) Confidence 0.42 Published 1979 Journal Oral Surg. Oral Med. Oral Pathol. Section Abstract Doc Link 284274 Disease Relevance 0.41 Pain Relevance 0.11
The common association between FMF and vasculitis makes pulmonary hemorrhage, infarction, or infiltrates highly possible.
FMF Binding (association) of associated with cva, infarction, increased venous pressure under development and fever
4) Confidence 0.42 Published 1999 Journal Curr Opin Pulm Med Section Abstract Doc Link 10461539 Disease Relevance 1.58 Pain Relevance 0.14
The authors also discuss the association of mesothelioma and FMF.
FMF Binding (association) of associated with lung cancer and fever
5) Confidence 0.42 Published 2009 Journal Rev Pneumol Clin Section Abstract Doc Link 19878808 Disease Relevance 1.01 Pain Relevance 0.19
FMF is also associated with subfertility.
FMF Binding (associated) of associated with fever
6) Confidence 0.38 Published 2003 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 12781406 Disease Relevance 1.92 Pain Relevance 0.14
Our study did not reveal any association between CD and FMF.
FMF Neg (not) Binding (association) of associated with celiac disease and fever
7) Confidence 0.38 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18351429 Disease Relevance 1.36 Pain Relevance 0.08
Recently, the SPRY (also known as B30.2) domain of the protein pyrin, which is encoded by the MEFV gene (Chr.16p13.3; GenBank NM_000243; OMIM 608107), has been reported to interact with and modulate the activity of several inflammasome components, including NALP3/cryopyrin, caspase-1, and, its substrate, pro-IL-1?
MEFV Binding (interact) of
8) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.59 Pain Relevance 0.22
Yet, the FMF causative mutations were reported to be associated with the other alleles of the exon 2 coding variants (i.e. rs224225, rs224224, rs224223, rs224222: TACG) in this population.
FMF Binding (associated) of associated with fever
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.81 Pain Relevance 0.11
flanking region of MEFV, was significantly associated with CD (p?
MEFV Binding (associated) of associated with crohn's disease
10) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 0.92 Pain Relevance 0.27
We subsequently sought to evaluate MEFV common variants for their association with IBD.
MEFV Binding (association) of associated with inflammatory bowel disease
11) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.22 Pain Relevance 0.16
Recently, the SPRY (also known as B30.2) domain of the protein pyrin, which is encoded by the MEFV gene (Chr.16p13.3; GenBank NM_000243; OMIM 608107), has been reported to interact with and modulate the activity of several inflammasome components, including NALP3/cryopyrin, caspase-1, and, its substrate, pro-IL-1?
pyrin Binding (interact) of
12) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.61 Pain Relevance 0.22
Additionally, the levels of association for the MEFV SNPs conditional on each individual's genotypes at NLPR3 are in the same order of magnitude than the unconditional levels of association (Figure S3), indicating that epistasis between the two genes is not a mechanism that would be a regulator of the risk of MEFV on UC.


MEFV Binding (association) of associated with inflammatory bowel disease
13) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.20 Pain Relevance 0.21
To our knowledge, no study has yet shown an association between FMF and cirrhosis of the liver.
FMF Binding (association) of in liver associated with cirrhosis and fever
14) Confidence 0.30 Published 2007 Journal Medicine (Baltimore) Section Abstract Doc Link 18004180 Disease Relevance 1.81 Pain Relevance 0.14
Our objective was clinical and genetic characterization of FMF and its development in pediatric patients who first presented with attacks of fever alone.
FMF Binding (characterization) of associated with fever
15) Confidence 0.28 Published 2010 Journal J. Rheumatol. Section Abstract Doc Link 20194447 Disease Relevance 0.90 Pain Relevance 0.10
We present the second patient with type 1 DM associated with FMF who also had ATD and CD.
FMF Binding (associated) of associated with celiac disease, thyroid disease and fever
16) Confidence 0.26 Published 2009 Journal Turk. J. Pediatr. Section Abstract Doc Link 19480334 Disease Relevance 1.87 Pain Relevance 0.17
Pyrin has some structural similarities to the NLR proteins and may interact with NLR inflammasomes or form its own inflammasome, resulting in dysregulated caspase-1 activation and IL-1?
Pyrin Binding (interact) of
17) Confidence 0.26 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.77 Pain Relevance 0.20
Pyrin has some structural similarities to the NLR proteins and may interact with NLR inflammasomes or form its own inflammasome, resulting in dysregulated caspase-1 activation and IL-1?
Pyrin Binding (similarities) of
18) Confidence 0.26 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.70 Pain Relevance 0.20
The FMF gene (MEFV) has been mapped to chromosome 16p13.3 and generates a protein found exclusively in granulocytes.
FMF gene Binding (mapped) of in granulocytes
19) Confidence 0.24 Published 2000 Journal Hum. Mutat. Section Abstract Doc Link 10737992 Disease Relevance 0.57 Pain Relevance 0.15
We emphasize the rare association of FMF and PAN and the non-aneurysmal angiographic signs of PAN.
FMF Binding (association) of associated with vasculitis and fever
20) Confidence 0.22 Published 2004 Journal Pediatr. Nephrol. Section Abstract Doc Link 14963762 Disease Relevance 1.37 Pain Relevance 0.12

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