INT19010

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 27
Total Number 29
Disease Relevance 4.85
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 12
hypothalamus 2
plasma 2
arcuate nucleus 2
neurons 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 74 100.00 Very High Very High Very High
Clonidine 53 100.00 Very High Very High Very High
adenocard 7 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
Neurotransmitter 39 99.54 Very High Very High Very High
antagonist 89 99.50 Very High Very High Very High
anesthesia 6 99.32 Very High Very High Very High
Potency 4 98.08 Very High Very High Very High
opiate 6 95.88 Very High Very High Very High
tetrodotoxin 4 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 44 99.76 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

15 99.16 Very High Very High Very High
Obesity 32 98.84 Very High Very High Very High
Hyperglycemia 2 98.52 Very High Very High Very High
Weight Gain 1 93.08 High High
Starvation 21 88.60 High High
Pressure And Volume Under Development 7 88.32 High High
Appetite Loss 2 86.72 High High
Hypertension 9 85.12 High High
Immunization 3 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that reduction of both hypothalamic GRF and somatostatin release contribute to the impaired GH secretion in VMH lesioned rats.
Negative_regulation (reduction) of Localization (release) of GRF associated with somatostatin
1) Confidence 0.57 Published 1993 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 8101181 Disease Relevance 0 Pain Relevance 0.47
These results suggest that GH autofeedback is mediated by reduced GRF secretion, rather than enhanced SRIF release.
Negative_regulation (reduced) of Localization (secretion) of GRF associated with somatostatin
2) Confidence 0.54 Published 1985 Journal Endocrinology Section Abstract Doc Link 2866085 Disease Relevance 0.08 Pain Relevance 0.61
Results from similar studies conducted on middle-aged arcuate nucleus-lesioned rats suggest that a decline in GRF secretion is a possible contributor to the age-associated alterations in plasma growth hormone profiles during middle age.
Negative_regulation (decline) of Localization (secretion) of GRF in arcuate nucleus
3) Confidence 0.53 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11792682 Disease Relevance 0 Pain Relevance 0.26
The stimulatory effect of clonidine (10(-4) M) on GRF release in the presence of propranolol was inhibited by yohimbine (10(-4) M), an alpha 2-adrenergic blocking agent.
Negative_regulation (inhibited) of Localization (release) of GRF associated with clonidine
4) Confidence 0.43 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.27
These results suggest that hyperglycemia does not change the GH response to GHRF and that elevation of plasma FFA suppresses GHRF-induced GH secretion by the stimulation of somatostatin secretion in rats.
Negative_regulation (suppresses) of Localization (secretion) of GHRF-induced in plasma associated with hyperglycemia and somatostatin
5) Confidence 0.43 Published 1986 Journal Endocrinology Section Abstract Doc Link 2870916 Disease Relevance 0.32 Pain Relevance 0.12
Orchidectomy on day 83 reduced this GHRH-induced GH secretion on day 90.
Negative_regulation (reduced) of Localization (secretion) of GHRH
6) Confidence 0.43 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2109443 Disease Relevance 0 Pain Relevance 0.08
While basal GH secretion from the cultured pituitary cells was similar in the two groups (49.7 +/- 3.5 vs. 47.8 +/- 2.7 ng/ml X 4 h for the 2- and 18-month old rats, respectively), the GH-releasing ability of GRF was partially but significantly impaired in cells derived from both 14- and 18-month old rats; 100 nM GRF stimulated the release of 96.7 +/- 1.8 ng/ml X 4 h in the 18-month old rats as opposed to 115.0 +/- 6.0 (P less than 0.05) ng/ml X 4 h in the 2-month-old rats.
Negative_regulation (ability) of Localization (releasing) of GRF in pituitary
7) Confidence 0.42 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.31 Pain Relevance 0.08
Although the actions of dermorphin, 2549, and GHRP on GH release are GHRH dependent, release of endogenous GHRH does not explain how GH is released synergistically by the combination of these peptides.
Neg (not) Negative_regulation (explain) of Localization (release) of GHRH
8) Confidence 0.41 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.71
The alpha 2 antagonist idazoxan (2 mg/kg i.v.) prevented release due to intravenous clonidine, morphine and quipazine, but not GH-releasing factor (GRF) 25 micrograms/kg.
Negative_regulation (prevented) of Localization (release) of GRF associated with antagonist, morphine and clonidine
9) Confidence 0.40 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8105397 Disease Relevance 0 Pain Relevance 1.65
Replacing extracellular Na+ with mannitol or tris(hydroxymethyl)aminomethane (Tris+) suppressed hGRF- and dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP)-induced GH secretion.
Negative_regulation (suppressed) of Localization (secretion) of hGRF associated with adenocard
10) Confidence 0.40 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.11
These data and observations by others indicate that specific suppression of GH secretion in MS may derive from a reduction in GRF release through noradrenergic neurons, possibly impinging upon serotonergic terminals in the hypothalamus.
Negative_regulation (reduction) of Localization (release) of GRF in hypothalamus
11) Confidence 0.39 Published 1996 Journal Psychoneuroendocrinology Section Abstract Doc Link 8774064 Disease Relevance 0 Pain Relevance 0.54
Under pentobarbital anesthesia in which endogenous somatostatin secretion is known to be decreased, KP-102 and GHRH, both showed an almost equivalent GH-releasing potency, which was also similar to that of KP-102 in conscious rats.
Negative_regulation (decreased) of Localization (secretion) of GHRH associated with anesthesia, somatostatin and potency
12) Confidence 0.37 Published 2004 Journal Arzneimittelforschung Section Abstract Doc Link 15646370 Disease Relevance 0 Pain Relevance 0.23
A significant decrease of GRF-stimulated GH secretion of lean rat pituitary cells exposed to the obese serum was noted (P less than 0.05).
Negative_regulation (decrease) of Localization (secretion) of GRF in pituitary associated with obesity
13) Confidence 0.35 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 0.87 Pain Relevance 0.04
In addition they suggest that impairment of GH secretion in thyroidectomized rats does not depend upon changes in the hypothalamic SRIF regulation of the hormone but could be dependent on a defect in GRF release and/or, most probably, GH synthesis directly at the pituitary level.
Negative_regulation (defect) of Localization (release) of GRF in pituitary associated with somatostatin
14) Confidence 0.32 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0 Pain Relevance 0.28
NPY stimulates basal GH secretion in rat pituitary cells loaded on a Bio-Gel P-2 column (237), in porcine monolayer cultures (238) and in gold fish pituitary fragments (239), but inhibits GHRH-stimulated GH release in porcine pituitary cultures (238).


Negative_regulation (inhibits) of Localization (release) of GHRH in pituitary
15) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.08
In sheep, treatment with leptin for 1–3 days reduces mRNA levels of GH and GHRH-R in the pituitary, and decreases the GH secretory response to GHRH (449).
Negative_regulation (decreases) of Localization (secretory) of GHRH in pituitary
16) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.50 Pain Relevance 0
These observations suggest that radiation damage may sometimes spare growth hormone-releasing hormone (GHRH) and somatostatin secretion while affecting neurotransmitter pathways.
Spec (may) Negative_regulation (spare) of Localization (secretion) of growth hormone-releasing hormone associated with neurotransmitter and somatostatin
17) Confidence 0.24 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 8102303 Disease Relevance 0.06 Pain Relevance 0.45
These observations suggest that radiation damage may sometimes spare growth hormone-releasing hormone (GHRH) and somatostatin secretion while affecting neurotransmitter pathways.
Spec (may) Negative_regulation (spare) of Localization (secretion) of GHRH associated with neurotransmitter and somatostatin
18) Confidence 0.24 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 8102303 Disease Relevance 0.06 Pain Relevance 0.45
As compared with basal levels, incubation of hypothalami with hGH increased IGF-I and SRIF and decreased GRF release.
Negative_regulation (decreased) of Localization (release) of GRF associated with somatostatin
19) Confidence 0.24 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0 Pain Relevance 0.20
CLON-induced GH release in this system was associated with increased GRF and decreased SRIF release, and the pattern was reversed by hGH.
Negative_regulation (decreased) of Localization (release) of GRF associated with somatostatin
20) Confidence 0.23 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0.08 Pain Relevance 0.29

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