INT190110

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.47
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Eri1) RNA binding (Eri1) rRNA binding (Eri1)
nucleus (Eri1) intracellular (Eri1) cytoplasm (Eri1)
Anatomy Link Frequency
nerve 1
Eri1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 25 85.60 High High
Neurotransmitter 5 85.24 High High
Central nervous system 8 68.16 Quite High
medulla 5 54.96 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 5 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 240 99.66 Very High Very High Very High
Viral Meningitis 29 99.48 Very High Very High Very High
Cytomegalovirus Infection 16 99.36 Very High Very High Very High
Infection 38 94.76 High High
Parkinson's Disease 25 89.84 High High
Disease 35 89.64 High High
Death 38 76.08 Quite High
Sprains And Strains 10 67.36 Quite High
Contagious Ecthyma 15 60.32 Quite High
Reprotox - General 3 5 35.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CMV-Cre transgenic mice express Cre recombinase ubiquitously 32, and thus, the PINK1 RNAi transgene can be activated in every tissue.
Positive_regulation (activated) of RNAi associated with targeted disruption and cytomegalovirus infection
1) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.79 Pain Relevance 0
In these transgenic mice, the expression of the PINK1 shRNA was tightly regulated by the Cre-loxP system and activation of the RNAi transgene resulted in silenced expression of the Pink1 gene in various tissues and to less than 5% of the normal levels in the central nerve system.
Positive_regulation (activation) of RNAi in nerve associated with targeted disruption
2) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.96 Pain Relevance 0
After crossing with the CMV-Cre transgenic mice, the PINK1 RNAi transgene was activated by Cre-mediated excision of the intervening sequence from the promoter region.
Positive_regulation (activated) of RNAi associated with targeted disruption and cytomegalovirus infection
3) Confidence 0.19 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.58 Pain Relevance 0.06
Inducible RNAi based on the Cre-loxP system has also been developed in transgenic mice, and it enables the investigator to control gene silencing spatially and temporally 13, 16, 37.
Positive_regulation (Inducible) of RNAi associated with targeted disruption
4) Confidence 0.18 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.49 Pain Relevance 0.09
RNAi is induced by short double-stranded RNA called small interfering RNA (siRNA), of which one strand (guide strand) is incorporated into RNA-Induced Silencing Complex (RISC) and directs localization and degradation of targeted RNA molecules with complementary sequence to the siRNA guide strand 4-6.
Positive_regulation (induced) of RNAi
5) Confidence 0.18 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1820878 Disease Relevance 0.09 Pain Relevance 0
To induce RNAi, we used either lentivirally expressed short hairpin RNA (shRNA) or synthetic short interfering RNA (siRNA).
Positive_regulation (induce) of RNAi
6) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1361782 Disease Relevance 0.57 Pain Relevance 0

General Comments

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