INT190146

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA, JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) DNA binding (JUN) peptidase activity (MMP12)
Anatomy Link Frequency
smooth muscle cells 3
PIK3CA (Homo sapiens)
JUN (Homo sapiens)
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 151 100.00 Very High Very High Very High
corticosteroid 8 97.76 Very High Very High Very High
cINOD 1 96.16 Very High Very High Very High
dexamethasone 7 72.00 Quite High
Inflammation 22 29.12 Quite Low
cytokine 20 28.08 Quite Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 95.76 Very High Very High Very High
Asthma 12 92.16 High High
Pulmonary Disease 16 91.28 High High
Airway Remodeling 5 65.12 Quite High
Emphysema 3 60.00 Quite High
Cough 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vascular smooth muscle cells, PI3-kinase activation appears to be required for MMP-12 transcriptional activity through AP-1 binding to the gene promoter [23].
Positive_regulation (activation) of PI3-kinase in smooth muscle cells Positive_regulation (required) of AP-1 Binding (binding) of MMP-12 in smooth muscle cells associated with metalloproteinase
1) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.57 Pain Relevance 0.57

General Comments

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