INT190146

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.57

cytosol (PIK3CA, JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) DNA binding (JUN) peptidase activity (MMP12)

Anatomy Link Frequency smooth muscle cells 3 PIK3CA (Homo sapiens) JUN (Homo sapiens) MMP12 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 151 100.00 corticosteroid 8 97.76 cINOD 1 96.16 dexamethasone 7 72.00 Inflammation 22 29.12 cytokine 20 28.08 Inflammatory mediators 2 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 26 95.76 Asthma 12 92.16 Pulmonary Disease 16 91.28 Airway Remodeling 5 65.12 Emphysema 3 60.00 Cough 4 5.00 Necrosis 3 5.00 Cancer 3 5.00 Disease 2 5.00 Nicotine Addiction 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vascular smooth muscle cells, PI3-kinase activation appears to be required for MMP-12 transcriptional activity through AP-1 binding to the gene promoter [23].

Positive_regulation (activation) of PI3-kinase in smooth muscle cells Positive_regulation (required) of AP-1 Binding (binding) of MMP-12 in smooth muscle cells associated with metalloproteinase

1) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.57 Pain Relevance 0.57

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