INT190147

Context Info Confidence 0.03 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.87 Pain Relevance 0.90

extracellular region (MMP12, MMP2, MMRN1) peptidase activity (MMP12, MMP2) proteinaceous extracellular matrix (MMP12, MMP2) extracellular space (MMP2) cell adhesion (MMRN1) plasma membrane (MMP2)

MMP12 (Homo sapiens) MMP2 (Homo sapiens) MMRN1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 151 100.00 Inflammation 22 96.40 cytokine 20 77.36 Inflammatory mediators 2 27.44 corticosteroid 8 5.00 dexamethasone 7 5.00 cINOD 1 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 26 96.40 Airway Remodeling 5 86.08 Nicotine Addiction 1 83.40 Respiratory Disease 1 59.76 Asthma 12 57.20 Pulmonary Disease 16 56.32 Targeted Disruption 1 51.04 Disease 2 48.24 Emphysema 3 44.56 Cough 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, MMP-12 can activate other MMPs, for example, MMP-2 and -3, leading to subsequent degradation of other ECM proteins [10].

MMP-12 Positive_regulation (activate) of MMP-2 Positive_regulation (leading) of Protein_catabolism (degradation) of ECM associated with metalloproteinase

1) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.87 Pain Relevance 0.90

General Comments

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