INT190182

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN)
DNA binding (JUN) cytosol (JUN) peptidase activity (MMP12)
Anatomy Link Frequency
macrophages 1
JUN (Homo sapiens)
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 151 100.00 Very High Very High Very High
cytokine 20 94.16 High High
Inflammatory stimuli 1 83.12 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 82.80 Quite High
Pulmonary Disease 16 5.00 Very Low Very Low Very Low
Asthma 12 5.00 Very Low Very Low Very Low
Airway Remodeling 5 5.00 Very Low Very Low Very Low
Cough 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Emphysema 3 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Removal of the AP-1 binding site from the MMP-12 promoter abolished the basal and inducible expression of MMP-12 [23]. c-Jun, which is a predominant component of the AP-1 binding complex binding to the MMP-12 promoter [23], can potentially transactivate the MMP-12 promoter up to 20-fold in macrophages [18].
Jun Positive_regulation (transactivate) of MMP-12 promoter in macrophages associated with metalloproteinase
1) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.08 Pain Relevance 0.80

General Comments

This test has worked.

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