INT190189

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.87
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP12) extracellular region (MMP12) proteinaceous extracellular matrix (MMP12)
Anatomy Link Frequency
macrophage 2
MMP12 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 605 100.00 Very High Very High Very High
cytokine 85 99.80 Very High Very High Very High
Inflammation 96 98.36 Very High Very High Very High
corticosteroid 32 93.16 High High
cINOD 4 84.64 Quite High
dexamethasone 28 83.20 Quite High
Inflammatory stimuli 4 73.36 Quite High
Inflammatory mediators 8 62.80 Quite High
imagery 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 20 98.96 Very High Very High Very High
INFLAMMATION 112 98.36 Very High Very High Very High
Pulmonary Disease 64 93.92 High High
Foreign Bodies 2 89.56 High High
Asthma 48 85.32 High High
Emphysema 12 82.80 Quite High
Airway Remodeling 20 80.80 Quite High
Osteoporosis 9 74.56 Quite High
Hypercalcemia 2 70.40 Quite High
Cancer 35 45.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
enhanced MMP-12 secretion and activity of ASMC in a time- and concentration-dependent manner, with an up to 10-fold increase to control levels, as determined by gelatin zymography.
Positive_regulation (enhanced) of Localization (secretion) of MMP-12 associated with metalloproteinase
1) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.54 Pain Relevance 0.60
stimulates a significant enhancement in MMP-12 gene expression, protein production and enzyme secretion, which is mediated by mechanisms involving ERK, JNK, PI3-K and AP-1 signaling pathways.
Positive_regulation (enhancement) of Localization (secretion) of MMP-12 gene associated with metalloproteinase
2) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.25 Pain Relevance 1.17
Abundant VEGF and MMP12 were secreted from both tumoural and non-tumoural cells, and these cytokines promote macrophage migration and angiogenesis.
Positive_regulation (Abundant) of Localization (secreted) of MMP12 in macrophage associated with cytokine
3) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.71 Pain Relevance 0.14
-stimulated MMP-12 mRNA expression and secretion in ASMC.
Positive_regulation (stimulated) of Localization (secretion) of MMP-12 mRNA associated with metalloproteinase
4) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.30 Pain Relevance 0.53
Therefore, we examined whether these cytokines affected MMP-12 secretion mediated through regulation of c-Jun activity in ASMC.
Spec (whether) Positive_regulation (mediated) of Localization (secretion) of MMP-12 associated with metalloproteinase and cytokine
5) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.07 Pain Relevance 0.73

General Comments

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