INT190190

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.81
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ELN) extracellular region (ELN) proteinaceous extracellular matrix (ELN)
Anatomy Link Frequency
muscles 1
parenchyma 1
ELN (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 157 99.92 Very High Very High Very High
Inflammatory mediators 4 93.28 High High
Inflammation 115 92.40 High High
beta blocker 2 74.92 Quite High
cocaine 23 69.00 Quite High
ischemia 3 68.48 Quite High
cytokine 42 55.76 Quite High
Thoracotomy 1 47.48 Quite Low
rheumatoid arthritis 19 26.00 Quite Low
abdominal pain 4 25.20 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 123 97.68 Very High Very High Very High
Viral Meningitis 42 96.04 Very High Very High Very High
Hematoma 3 94.36 High High
INFLAMMATION 119 92.88 High High
Nicotine Addiction 11 92.28 High High
Marfan Syndrome 1 87.12 High High
Osteoporosis 1 87.04 High High
Disease 57 84.64 Quite High
Hypertrophy 1 80.20 Quite High
Calcification 1 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both these cell types release the matrix metalloproteinases that can degrade elastin.
Protein_catabolism (degrade) of elastin associated with metalloproteinase
1) Confidence 0.22 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 0.70 Pain Relevance 0.25
MMP-12 degrades a broad range of ECM proteins, including elastin, type IV collagen, fibronectin, laminin and gelatin [8,9], and is involved in turnover of the matrix, cell migration, tissue repairing and remodeling.
Protein_catabolism (degrades) of elastin associated with metalloproteinase
2) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.60 Pain Relevance 0.77
Additionally, both proteases degraded elastin (a major constituent of elastic fibers) in the zymographic assays, indicating that proteases from AGE isolate exhibit elastinolytic activities (Fig. 5).
Protein_catabolism (degraded) of elastin associated with viral meningitis
3) Confidence 0.17 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1464133 Disease Relevance 0.30 Pain Relevance 0
It is postulated that thinning of the media due to degeneration of collagen, elastin or muscles within the media (cystic medial degeneration), weakens the intima and predisposes it to tearing.
Protein_catabolism (degeneration) of elastin in muscles
4) Confidence 0.09 Published 2008 Journal Cases J Section Body Doc Link PMC2628897 Disease Relevance 0.63 Pain Relevance 0.07
COPD is characterized by a relevant imbalance between proteinases (serine elastases, cysteine proteinases, MMPs), which degrade elastin and other structural proteins of lung parenchyma, and the protective array of antiproteinases (?
Protein_catabolism (degrade) of elastin in parenchyma associated with pulmonary disease and metalloproteinase
5) Confidence 0.05 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.58 Pain Relevance 0.18

General Comments

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