INT1902

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2010
Negated 19
Speculated 14
Reported most in Abstract
Documents 348
Total Number 365
Disease Relevance 70.33
Pain Relevance 241.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
plasma 25
brain 20
neurons 14
hypothalamus 8
spinal 7
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 2372 100.00 Very High Very High Very High
Enkephalin 337 100.00 Very High Very High Very High
Morphine 284 100.00 Very High Very High Very High
Neuropeptide 235 100.00 Very High Very High Very High
substance P 208 100.00 Very High Very High Very High
antagonist 198 100.00 Very High Very High Very High
qutenza 165 100.00 Very High Very High Very High
Somatostatin 160 100.00 Very High Very High Very High
Neurotransmitter 159 100.00 Very High Very High Very High
Opioid 132 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 149 100.00 Very High Very High Very High
Urological Neuroanatomy 134 100.00 Very High Very High Very High
Generalized Anxiety Disorder 31 100.00 Very High Very High Very High
Abdominal Pain 13 100.00 Very High Very High Very High
Aids-related Complex 4 100.00 Very High Very High Very High
Viral Infection 2 100.00 Very High Very High Very High
Hyperalgesia 49 99.96 Very High Very High Very High
Fever 2 99.96 Very High Very High Very High
Anxiety Disorder 112 99.92 Very High Very High Very High
Gastrointestinal Disease 2 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a dramatic increase in the number of neurons in dorsal root ganglia synthesizing the peptide cholecystokinin (CCK) after sciatic nerve section.
Gene_expression (synthesizing) of peptide cholecystokinin in neurons associated with sciatic nerve and cholecystokinin
1) Confidence 0.78 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8515864 Disease Relevance 0.34 Pain Relevance 1.32
There was a dramatic increase in the number of neurons in dorsal root ganglia synthesizing the peptide cholecystokinin (CCK) after sciatic nerve section.
Gene_expression (synthesizing) of CCK in neurons associated with sciatic nerve and cholecystokinin
2) Confidence 0.78 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8515864 Disease Relevance 0.34 Pain Relevance 1.33
In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats.
Gene_expression (expressions) of CCK in nucleus associated with qutenza and cholecystokinin
3) Confidence 0.78 Published 2004 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 15242019 Disease Relevance 0.24 Pain Relevance 1.00
BACKGROUND/AIMS: Recently we showed that doses of cholecystokinin octapeptide (CCK-8) that produce physiological plasma CCK levels act via stimulation of afferent vagal pathway to mediate pancreatic enzyme secretion.
Gene_expression (produce) of CCK in plasma associated with cholecystokinin
4) Confidence 0.78 Published 1994 Journal Gastroenterology Section Abstract Doc Link 8039628 Disease Relevance 0 Pain Relevance 0.09
BACKGROUND/AIMS: Recently we showed that doses of cholecystokinin octapeptide (CCK-8) that produce physiological plasma CCK levels act via stimulation of afferent vagal pathway to mediate pancreatic enzyme secretion.
Gene_expression (produce) of cholecystokinin octapeptide in plasma associated with cholecystokinin
5) Confidence 0.78 Published 1994 Journal Gastroenterology Section Abstract Doc Link 8039628 Disease Relevance 0 Pain Relevance 0.09
The C-terminal tetrapeptide of CCK (CCK 4) and pentagastrin were found to be ineffective in all tests but caerulein and molluscan cardioexcitatory neuropeptide (FMRF-amide), like CCK 8, produced antinociception in the paw pressure test.
Gene_expression (produced) of CCK in paw associated with antinociception and neuropeptide
6) Confidence 0.78 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3670569 Disease Relevance 0.25 Pain Relevance 0.76
Cholecystokinin gene expression in rat amygdaloid neurons: normal distribution and effect of morphine tolerance.
Gene_expression (expression) of Cholecystokinin gene in neurons associated with tolerance, cholecystokinin and morphine
7) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.14
The present study demonstrated that repeated administration of morphine increased CCK gene expression in the amygdaloid complex, and suggested that the development of the tolerance to morphine analgesia is due, in part, to an increase in CCK activity in the amygdaloid complex.
Gene_expression (expression) of CCK associated with tolerance, cholecystokinin, analgesia and morphine
8) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.50
These findings substantiate the hypothesis that long-term administration of opioid may induce a compensatory increase in CCK synthesis and/or release, which then results in a progressive antagonism of opioid analgesia.
Gene_expression (synthesis) of CCK associated with cholecystokinin, opioid and analgesia
9) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.24
In this study, in situ hybridization histochemistry was used to examine the effect of morphine tolerance on CCK gene expression in the amygdala of rat brains, by using a 35S-labeled synthetic oligonucleotide probe.
Gene_expression (expression) of CCK in brains associated with tolerance, amygdala, cholecystokinin and morphine
10) Confidence 0.78 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170343 Disease Relevance 0 Pain Relevance 1.02
Therefore, we hypothesized that the P77PMC animals would show an enhanced analgesic response based on their decreased CCK levels producing a diminished endogenous opiate antagonism.
Gene_expression (producing) of CCK associated with analgesic, opiate and cholecystokinin
11) Confidence 0.78 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037405 Disease Relevance 0.29 Pain Relevance 1.31
No gastrin was found in the cord or in spinal roots or sensory ganglia, however CCK was present at all levels of the cord and was concentrated in the dorsal horn.
Gene_expression (present) of CCK in spinal associated with dorsal horn and cholecystokinin
12) Confidence 0.78 Published 1982 Journal Brain Res. Section Abstract Doc Link 7093671 Disease Relevance 0 Pain Relevance 0.75
The distribution of receptor internalization surrounds the distribution of CCK cells in the medial preoptic nucleus, suggesting that endogenous opioid peptides may modulate estrogen-induced CCK mRNA expression.
Gene_expression (expression) of CCK mRNA in medial preoptic nucleus associated with endogenous opioid and cholecystokinin
13) Confidence 0.78 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.18 Pain Relevance 1.35
The display of lordosis behavior has been correlated with the estrogen-induced expression of cholecystokinin (CCK) and enkephalin within the limbic-hypothalamic circuit.
Gene_expression (expression) of cholecystokinin associated with enkephalin, lordosis and cholecystokinin
14) Confidence 0.78 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.35 Pain Relevance 0.74
Together, these results suggest that endogenous opioid peptides may modulate the estrogenic upregulation of CCK mRNA expression and demonstrate an important level of regulation of gene expression in which synaptic activity modifies hormonal input.
Gene_expression (expression) of CCK mRNA associated with endogenous opioid and cholecystokinin
15) Confidence 0.78 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.05 Pain Relevance 1.05
The display of lordosis behavior has been correlated with the estrogen-induced expression of cholecystokinin (CCK) and enkephalin within the limbic-hypothalamic circuit.
Gene_expression (expression) of CCK associated with enkephalin, lordosis and cholecystokinin
16) Confidence 0.78 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.35 Pain Relevance 0.74
Interestingly, nonselective and delta-opiate receptor selective antagonists potentiated the estrogen-induced CCK mRNA expression in the medial preoptic nucleus.
Gene_expression (expression) of CCK mRNA in medial preoptic nucleus associated with antagonist, opiate and cholecystokinin
17) Confidence 0.78 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370197 Disease Relevance 0.17 Pain Relevance 1.21
These data suggest that regions outside the COOH terminus of rat CCK-58 influence the expression of CCK biological activity.
Gene_expression (expression) of CCK
18) Confidence 0.78 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14604858 Disease Relevance 0 Pain Relevance 0.07
Furthermore, it is suggested that CCK may not play a significant role in the phenomenon of wind-up and central sensitization after repetitive C-fiber input under normal conditions or after axotomy, when expression of CCK and CCK-B receptors are increased in sensory neurons.
Gene_expression (expression) of CCK in sensory neurons associated with c fibre, central sensitization and cholecystokinin
19) Confidence 0.78 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571648 Disease Relevance 0 Pain Relevance 0.83
Furthermore, it is suggested that CCK may not play a significant role in the phenomenon of wind-up and central sensitization after repetitive C-fiber input under normal conditions or after axotomy, when expression of CCK and CCK-B receptors are increased in sensory neurons.
Gene_expression (expression) of CCK in sensory neurons associated with c fibre, central sensitization and cholecystokinin
20) Confidence 0.78 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9571648 Disease Relevance 0 Pain Relevance 0.83

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