INT190277

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.68
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
MIR122 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 51.44 Quite High
aspirin 21 26.24 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Rsd 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 8 99.46 Very High Very High Very High
Gastrointestinal Neoplasms 6 98.96 Very High Very High Very High
Hepatocellular Cancer 3 98.76 Very High Very High Very High
Infection 18 84.88 Quite High
Sprains And Strains 9 79.76 Quite High
Viral Infection 10 70.04 Quite High
Metastasis 6 50.56 Quite High
Aids-related Complex 1 37.04 Quite Low
Cancer 42 5.00 Very Low Very Low Very Low
Helminth Infection 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of miR-122a expression in mutant APC cells induces a gain of wild type APC function, indicating that miR-122a works downstream of APC and suggests that miR-122a expression is lost or downregulated in APC-driven gastrointestinal cancers.
Gene_expression (expression) of miR-122a associated with gastrointestinal neoplasms
1) Confidence 0.58 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.16 Pain Relevance 0
The mechanism by which miR-122a expression bypasses loss-of-function APC is unknown.
Gene_expression (expression) of miR-122a
2) Confidence 0.58 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.32 Pain Relevance 0
Further, restoration of miR-122a expression significantly suppressed migration, invasion, anchorage-independent growth, and in vivo tumorigenicity of hepatocellular carcinoma cells.
Gene_expression (expression) of miR-122a associated with hepatocellular cancer
3) Confidence 0.58 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
Recently, Kim and Bartel (40) tested the effect of 67 pDSPs altering target sites for miR-1/206, miR-133 and miR-122 in the 3?
Gene_expression (/) of miR-122
4) Confidence 0.06 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0.08 Pain Relevance 0
In fact, a genetic interaction between miR-122 and the 5' noncoding region of the HCV genome was highlighted by mutational analyses of the predicted microRNA binding site and ectopic expression of miR-122 molecules containing compensatory mutations.
Gene_expression (expression) of miR-122 associated with hepatitis c virus infection
5) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0.41 Pain Relevance 0.03
They demonstrated that Hepatitis C Virus (HCV) replication requires the expression of the miR-122, an abundant liver-specific miRNA.
Gene_expression (expression) of miR-122 in liver associated with hepatitis c virus infection
6) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0.44 Pain Relevance 0

General Comments

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