INT190278

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0

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cytosol (CDKN2D) nucleus (CDKN2D) cytoplasm (CDKN2D)
Anatomy Link Frequency
P19 2
CDKN2D (Homo sapiens)
Pain Link Frequency Relevance Heat
Rsd 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 18 50.36 Quite High
Helminth Infection 28 28.96 Quite Low
Cytomegalovirus Infection 8 17.64 Low Low
Sprains And Strains 8 6.84 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low
Viral Infection 10 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Reflex Sympathetic Dystrophy 4 5.00 Very Low Very Low Very Low
Immunization 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gel mobility shift assays showed that the P19 protein of Cymbidium Ringspot Virus (CymRSV) exclusively binds to 21 nt-long dsRNA with 2 nt-long 3' overhanging ends, a characteristic of authentic siRNAs, but not to long ssRNA, dsRNA or ss siRNAs [27].
P19 Binding (binds) of in P19
1) Confidence 0.04 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0.05 Pain Relevance 0
The crystal structures of p19 from TBSV and the Carnation Italian Ringspot Virus (CIRV), bound to a 21 nt siRNA, demonstrated that tombusviral P19 protein acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA, in a sequence-independent manner [28,29].
p19 Binding (bound) of in P19
2) Confidence 0.03 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0 Pain Relevance 0

General Comments

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