INT190280

Context Info Confidence 0.65 First Reported 2006 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 12 Total Number 15 Disease Relevance 9.54 Pain Relevance 2.67

cytosol (DICER1) intracellular (DICER1) helicase activity (DICER1) cytoplasm (DICER1)

Anatomy Link Frequency T cell 5 thymus 1 DICER1 (Homo sapiens)

Pain Link Frequency Relevance Heat Arthritis 440 99.44 cytokine 110 99.42 Multiple sclerosis 640 97.64 Inflammation 152 91.04 medulla 1 57.12 Catecholamine 1 55.00 rheumatoid arthritis 40 32.24 addiction 4 24.72 Central nervous system 108 5.00 cINOD 20 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 464 99.44 Cancer 92 99.20 Pheochromocytoma 33 98.92 Neuroblastoma 50 98.04 Demyelinating Disease 708 97.64 Sprains And Strains 8 95.92 Cytomegalovirus Infection 8 95.52 Disease 360 95.08 INFLAMMATION 188 91.04 Death 117 87.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

At this stage, the primary mobile RNA silencing signal, presumably the 21 nt siRNA, is produced by a DICER-LIKE endonuclease (Dunoyer et al., 2005).

Gene_expression (produced) of DICER

1) Confidence 0.65 Published 2008 Journal Journal of Experimental Botany Section Body Doc Link PMC2486475 Disease Relevance 0.26 Pain Relevance 0

Thus, TSP1, CASP8, HIC1, DcR1, DcR2 and DR4 and RASSF1 were methylated frequently in both tumour types (Astuti et al. 2001c, Margetts et al. 2005).

Gene_expression (methylated) of DcR1 associated with cancer

2) Confidence 0.56 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.45 Pain Relevance 0.06

In this case increased DcR1 expression (about 66 fold) was the most marked.

Gene_expression (expression) of DcR1

3) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.57 Pain Relevance 0.18

In addition, DcR1 and DcR2 expression showed strong correlation (p < 0.01).

Gene_expression (expression) of DcR1

4) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.67 Pain Relevance 0.30

Intriguingly, only the CD8+ T cell associated DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in patients with RA, implying that altered TRAIL receptor profiles on CD8+ T cell subsets rather than on CD4+ T cells is more important in terms of disease severity.

Gene_expression (expression) of DcR1 in T cell associated with disease and arthritis

5) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.98 Pain Relevance 0.37

These data show a 35-fold increase in DcR1 expression with a 10-15-fold increase in the other markers.

Gene_expression (expression) of DcR1

6) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.92 Pain Relevance 0.36

The most dramatic change in the amount of TRAIL/TRAIL receptor present on peripheral blood lymphocytes of RA patients was the increased DcR1 expression seen in both CD4+ and CD8+ T cells.

Gene_expression (expression) of DcR1 in T cells associated with arthritis

7) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.87 Pain Relevance 0.26

Recently, elevated expression of DcR1 was detected in antigen specific T cells of patients with multiple sclerosis (MS) [22].

Gene_expression (expression) of DcR1 in T cells associated with multiple sclerosis

8) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.82 Pain Relevance 0.24

CD8+ T cell associated DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in RA patients

Gene_expression (expression) of DcR1 in T cell associated with arthritis

9) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.83 Pain Relevance 0.29

Interestingly only CD8+ T cell associated (Figure 4) but not CD4+ T cell associated (data not shown) DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in RA patients.

Gene_expression (expression) of DcR1 in T cell associated with arthritis

10) Confidence 0.26 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.84 Pain Relevance 0.30

Cytokines have been shown to regulate Dicer expression resulting in alteration of pre-miRNA processing.

Gene_expression (expression) of Dicer associated with cytokine

11) Confidence 0.09 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.16 Pain Relevance 0.14

has been shown to inhibit Dicer expression, which results in decrease of pre-miRNA processing, whereas IFN-?

Gene_expression (expression) of Dicer

12) Confidence 0.09 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.15 Pain Relevance 0.14

Dicer facilitates, in a cell-autonomous fashion, the development of Treg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor-beta (TGF-?).

Gene_expression (induction) of Dicer in thymus

13) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.06 Pain Relevance 0.03

After Dicer processing, the miRNA duplex is unwound and a strand (known as miRNA strand or guide strand) binds to an Argonaute 2 (Ago 2) protein (eIF2C2 in human) in a process that is referred to as miRNA loading or assembly, while the complementary strand (known as miRNA* strand, star strand or passenger strand) is degraded.

Gene_expression (processing) of Dicer

14) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.14 Pain Relevance 0

The Dicer like 2 (DCL-2) was shown to produce the siRNAs derived from the turnip crinkle virus (TCV), but not those from the cucumber mosaic virus strain Y (CMV-Y) or the turnip mosaic virus (TMV).

Gene_expression (produce) of Dicer associated with cytomegalovirus infection and sprains and strains

15) Confidence 0.07 Published 2006 Journal Retrovirology Section Body Doc Link PMC1363733 Disease Relevance 0.81 Pain Relevance 0

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