INT190335

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.60
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 8
leaf 2
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 269 100.00 Very High Very High Very High
Inflammatory response 14 97.54 Very High Very High Very High
Inflammation 68 96.40 Very High Very High Very High
Spinal cord 32 92.12 High High
intrathecal 1 84.12 Quite High
antagonist 20 84.00 Quite High
chemokine 12 73.12 Quite High
Glutamate 1 67.84 Quite High
imagery 8 64.88 Quite High
alcohol 1 50.88 Quite High
Disease Link Frequency Relevance Heat
Toxicity 38 99.90 Very High Very High Very High
Chlamydia Infection 2 99.64 Very High Very High Very High
Bacterial Respiratory Disease 2 98.22 Very High Very High Very High
INFLAMMATION 83 97.36 Very High Very High Very High
Targeted Disruption 30 95.68 Very High Very High Very High
Eczema 109 94.48 High High
Cancer 138 93.08 High High
Multiple Sclerosis 41 93.08 High High
Fowlpox 18 89.24 High High
Recurrence 65 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Without longitudinal repeat measurements it is unclear if a pro-inflammatory response was at one time induced in these children or if the down-regulatory response was over zealous or abnormally sustained and prevented induction of an IFN-?
Negative_regulation (prevented) of Positive_regulation (induction) of IFN associated with inflammatory response
1) Confidence 0.42 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.51 Pain Relevance 0.08
Juglone (1 ┬ÁM) completely blocked the accumulation of I/P-induced IFN-?
Negative_regulation (blocked) of Positive_regulation (accumulation) of IFN
2) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.23 Pain Relevance 0.17
Therefore, this FX cream is expected as a useful skin care agent for atopic dry skin colonized by SA.3,4 Recently, we also found that AD-like lesions in DS-Nh of AD model mouse mice were significantly improved together with a decrease in number of SA detected from these lesions by treatment with the bamboo leaf extract cream having the antibacterial, viral and mycotic activity.5 This improvement effect was also observed together with a decrease of the increased serum IgE levels and IFN-?
Negative_regulation (decrease) of Positive_regulation (increased) of IFN in leaf associated with bacterial respiratory disease and eczema
3) Confidence 0.42 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.70 Pain Relevance 0.03
Patients successfully cured demonstrated downregulation of IL-12 and IL-10 in plasma, and two-fold or more elevation of IFN-?
Negative_regulation (downregulation) of Positive_regulation (elevation) of IFN in plasma
4) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.28 Pain Relevance 0.08
A differential immune profile, involving insignificant decline in IL-10 and IL-12 in plasma and negligible elevation of IFN-?
Negative_regulation (decline) of Positive_regulation (elevation) of IFN in plasma
5) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.30 Pain Relevance 0.07
A significant downregulation of IL-12 and IL-10 in the plasma, elevation of IFN-?
Negative_regulation (downregulation) of Positive_regulation (elevation) of IFN in plasma
6) Confidence 0.41 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.19 Pain Relevance 0.05
and IL-6 secretion, we could demonstrate a direct correlation between decreased IL-6 and increased IFN-?
Negative_regulation (decreased) of Positive_regulation (increased) of IFN
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.64 Pain Relevance 0.03
In the presence of BZ194, the TMBP-GFP cells produced significantly lower levels of IFN?
Negative_regulation (lower) of Positive_regulation (levels) of IFN
8) Confidence 0.41 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.40 Pain Relevance 0.50
This would be similar to the proposed retention of select tryptophan biosynthetic genes in Chlamydia spp. in order to replenish tryptophan pools after host enzymatic degradation of tryptophan in response to IFN-?
Negative_regulation (replenish) of Positive_regulation (response) of IFN associated with chlamydia infection
9) Confidence 0.41 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.10 Pain Relevance 0.03
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Negative_regulation (inhibitor) of Positive_regulation (concentrations) of IFN associated with cytokine
10) Confidence 0.41 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
Phosphorylation of extracts from untreated cells with two different concentrations of CK2 reduced the binding of Sp1/Sp3 to levels observed in IFN-?
Negative_regulation (levels) of Positive_regulation (observed) of IFN
11) Confidence 0.41 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
Panels A and B in Figure 3 show the concentrations of the Th1 cytokines, IL-2 and IFN-?
Negative_regulation (show) of Positive_regulation (concentrations) of IFN associated with cytokine
12) Confidence 0.41 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.09
A very limited number of activated IFN-?
Negative_regulation (limited) of Positive_regulation (activated) of IFN
13) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.25 Pain Relevance 0
Splenectomy markedly inhibited the BDL-induced increase in plasma IFN-?.


Negative_regulation (inhibited) of Positive_regulation (increase) of IFN in plasma
14) Confidence 0.41 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.10
Although two patients also developed detectable levels of IFN-?
Negative_regulation (developed) of Positive_regulation (levels) of IFN
15) Confidence 0.41 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 0.52 Pain Relevance 0
related grade 3/4 toxicity was predefined as a requirement for IFN-?
Negative_regulation (predefined) of Positive_regulation (requirement) of IFN associated with toxicity
16) Confidence 0.41 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.49 Pain Relevance 0

General Comments

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